The pharmacological characterization of FK 739, a new angiotensin II-receptor antagonist
K Hamada, Y Nakajima, H Nirei, C Nakajima… - The Japanese Journal …, 1993 - jstage.jst.go.jp
The pharmacological properties of FK 739, a new angiotensin 11-receptor antagonist, were
ex amined. FK 739 inhibited the specific binding of [125I1-angiotensin II to rat aortic smooth …
ex amined. FK 739 inhibited the specific binding of [125I1-angiotensin II to rat aortic smooth …
Induction of angiotensin I-converting enzyme in rat lung with captopril (SQ 14225)
F Fyhrquist, T Forslund, I Tikkanen… - European journal of …, 1980 - Elsevier
Angiotensin I-converting enzyme (ACE, EC 3.4. 15.1.) was measured in serum and in
pulmonary plasma membranes of 140 spontaneously hypertensive rats (SHR, Okamoto Aoki …
pulmonary plasma membranes of 140 spontaneously hypertensive rats (SHR, Okamoto Aoki …
(R)-3-[(S)-1-Carboxy-5-(4-Piperidyl) pentyl] amino-4-Oxo-2, 3, 4, 5-Tetrahydro-1, 5-Benzothiazepine-5-Acetic Acid (CV-5975): A New Potent and Long-Lasting …
Y INADA, I Katsumi, K KAMIYA, H SUGIHARA… - Japanese journal of …, 1988 - Elsevier
The synthetic design and the biological activities of structurally new angiotensin converting
enzyme (ACE) inhibitors,(R)-3-amino-4-oxo-2, 3, 4, 5-tetrahydro-1, 5-benzothiazepine-5 …
enzyme (ACE) inhibitors,(R)-3-amino-4-oxo-2, 3, 4, 5-tetrahydro-1, 5-benzothiazepine-5 …
Studies on angiotensin I converting enzyme (ACE): Inhibitory effect of imidapril, a novel ACE inhibitor (II). Inhibition of various tissue ACEs ex vivo
Y Hashimoto, M Kubo, T Sugaya, S Minobe… - Nihon Yakurigaku …, 1994 - europepmc.org
The antihypertensive mechanism of imidapril was investigated in relation to its inhibition of
ACE activities in the serum, thoracic-abdominal aorta, lung, kidney, heart and brain from …
ACE activities in the serum, thoracic-abdominal aorta, lung, kidney, heart and brain from …
In vivo comparison of three orally active inhibitors of angiotensin-converting enzyme
Y Takata, R Dinicolantonio, JS Hutchinson… - The American Journal of …, 1982 - Elsevier
This study was designed to compare the activity of three structurally different drugs (SQ
14225 [captopril], SA 446 and MK 421) as inhibitors of angiotensin I-converting enzyme in …
14225 [captopril], SA 446 and MK 421) as inhibitors of angiotensin I-converting enzyme in …
Effect of acute oral administration of captopril and MK-421 on vascular angiotensis converting enzyme activity in the spontaneously hypertensive rat
ML Cohen, KS Wiley, KD Kurz - Life Sciences, 1983 - Elsevier
Vascular angiotensin converting enzyme (ACE) may be important as a potential site of
action for the antihypertensive effect of ACE inhibitors. ACE activity, estimated by hydrolysis …
action for the antihypertensive effect of ACE inhibitors. ACE activity, estimated by hydrolysis …
Antihypertensive action of a novel orally active angiotensin converting enzyme inhibitor altiopril calcium (MC-838) in several hypertensive models of rats: comparison …
J Aono, T Koga, T Yamazaki, Y Shiraki… - … de pharmacodynamie et …, 1988 - europepmc.org
The antihypertensive effects of altiopril calcium (MC-838), calcium (-)-N-[(S)-3-[(N-
cyclohexylcarbonyl-D-alanyl) thio]-2-methyl-propionyl]-L-prolinate, a novel inhibitor of …
cyclohexylcarbonyl-D-alanyl) thio]-2-methyl-propionyl]-L-prolinate, a novel inhibitor of …
Effects of a new angiotensin-converting enzyme inhibitor, MK 421, in normal men and patients
T Kono, F OSEKO, F IKEDA, R NAKANO… - Endocrinologia …, 1982 - jstage.jst.go.jp
Abstract Effects of MK 421, a new angiotensin-converting enzyme inhibitor, were studied in
normal men and patients. MK 421 was given at 0900 h as a single oral dose of 20 mg, to 5 …
normal men and patients. MK 421 was given at 0900 h as a single oral dose of 20 mg, to 5 …
Studies on Angiotensin Converting Enzyme Inhibitors. II. Syntheses and Angiotensin Converting Enzyme Inhibitory Activities of Carboxyethylcarbamoyl-1, 2, 3, 4 …
K HAYASHI, K NUNAMI, K SAKAI, Y OZAKI… - Chemical and …, 1983 - jstage.jst.go.jp
The in vitro angiotensin converting enzyme (ACE) inhibitory activities of these dicarboxylic
acid derivatives (V) were evaluated. Among them, N-ethyl (13) and N-isopropyl (14) …
acid derivatives (V) were evaluated. Among them, N-ethyl (13) and N-isopropyl (14) …