Background and objectives of review: The use of aminoglycoside drops in the presence of a
perforation/grommet is still a common practice amongst the UK ENT community, in spite of …

Topical aminoglycoside ear drops are theoretically acknowledged to be potentially ototoxic
when administered in the presence of a tympanic membrane perforation. Although the …

Although experimental data confirm the presence of ototoxicity due to topical ear drops, the
clinical relevance still remains debatable. Only few case reports document sensorineural …

A discharging ear is a very common condition for the general practitioner and the ENT
surgeon. Oral and intravenous antibiotics have potential complications, are costly, and …

Otic drops commonly are used to treat chronic otitis media when there is a tympanic
membrane perforation. Drops also are used for otorrhea when a ventilation tube is in place …

Various topical preparations are widely used for treating external otitis, acute otitis media
with perforation, post-tympanostomy tube otorrhea, and chronic suppurative otitis media …

In this article we review the literature concerning the capacity of certain substances to cause
ototoxicity when administered topically. The ototoxicity experimentally observed in animals …

Ototoxicity after parenteral aminoglycoside administration is a well-documented adverse
effect involving this class of antibiotics. 1 Less well appreciated is the potential for inner ear …

OBJECTIVE: We sought to determine the incidence of injury to the cochlea or vestibular
system from the use of ototopic antibiotic ear drops. STUDY DESIGN: We conducted a …

An estimated 1.5% of the adult population in the United Kingdom has active chronic otitis
media with perforated tympanic membranes; this is comparable to the prevalence in western …