[HTML][HTML] Targeting biofilms therapy: current research strategies and development hurdles

Y Jiang, M Geng, L Bai - Microorganisms, 2020 - mdpi.com
Biofilms are aggregate of microorganisms in which cells are frequently embedded within a
self-produced matrix of extracellular polymeric substance (EPS) and adhere to each other …

Eradicating biofilm infections: an update on current and prospective approaches

RAG da Silva, I Afonina, KA Kline - Current Opinion in Microbiology, 2021 - Elsevier
Highlights•Biofilm infections are heterogenous, persistent and recalcitrant.•The rise of
antibiotic resistance necessitates new therapeutic strategies to eradicate biofilms.•The …

Targeting microbial biofilms: current and prospective therapeutic strategies

H Koo, RN Allan, RP Howlin, P Stoodley… - Nature Reviews …, 2017 - nature.com
Biofilm formation is a key virulence factor for a wide range of microorganisms that cause
chronic infections. The multifactorial nature of biofilm development and drug tolerance …

Beneficial applications of biofilms

LA Philipp, K Bühler, R Ulber, J Gescher - Nature Reviews Microbiology, 2023 - nature.com
Many microorganisms live in the form of a biofilm. Although they are feared in the medical
sector, biofilms that are composed of non-pathogenic organisms can be highly beneficial in …

Biofilms: Survival and defense strategy for pathogens

A Kumar, A Alam, M Rani, NZ Ehtesham… - International Journal of …, 2017 - Elsevier
Studies on biofilm related infections are gaining prominence owing to their involvement in
majority of clinical infections. Biofilm, considered as a generic mechanism for survival used …

Strategies for antimicrobial drug delivery to biofilm

C Martin, W LiLow, A Gupta… - Current …, 2015 - ingentaconnect.com
Biofilms are formed by the attachment of single or mixed microbial communities to a variety
of biological and/or synthetic surfaces. Biofilm micro-organisms benefit from many …

[HTML][HTML] Combination therapies for biofilm inhibition and eradication: a comparative review of laboratory and preclinical studies

S Hawas, AD Verderosa, M Totsika - Frontiers in cellular and infection …, 2022 - frontiersin.org
Microbial biofilms are becoming increasingly difficult to treat in the medical setting due to
their intrinsic resistance to antibiotics. To combat this, several biofilm dispersal agents are …

Novel approaches to combat bacterial biofilms

C Beloin, S Renard, JM Ghigo, D Lebeaux - Current opinion in …, 2014 - Elsevier
Highlights•Currently used antibiotics were developed to target planktonic bacteria.•Recent
discoveries on biofilm properties led to promising anti-biofilm strategies.•Biofilm inhibition …

[HTML][HTML] Combating bacterial biofilms: current and emerging antibiofilm strategies for treating persistent infections

AG Abdelhamid, AE Yousef - Antibiotics, 2023 - mdpi.com
Biofilms are intricate multicellular structures created by microorganisms on living (biotic) or
nonliving (abiotic) surfaces. Medically, biofilms often lead to persistent infections, increased …

Applying insights from biofilm biology to drug development—can a new approach be developed?

T Bjarnsholt, O Ciofu, S Molin, M Givskov… - Nature reviews Drug …, 2013 - nature.com
Most of the research on bacterial pathogenesis has focused on acute infections, but much
less is known about the pathogenesis of infections caused by bacteria that grow as …