[HTML][HTML] Targeting biofilms therapy: current research strategies and development hurdles
Y Jiang, M Geng, L Bai - Microorganisms, 2020 - mdpi.com
Biofilms are aggregate of microorganisms in which cells are frequently embedded within a
self-produced matrix of extracellular polymeric substance (EPS) and adhere to each other …
self-produced matrix of extracellular polymeric substance (EPS) and adhere to each other …
Eradicating biofilm infections: an update on current and prospective approaches
Highlights•Biofilm infections are heterogenous, persistent and recalcitrant.•The rise of
antibiotic resistance necessitates new therapeutic strategies to eradicate biofilms.•The …
antibiotic resistance necessitates new therapeutic strategies to eradicate biofilms.•The …
Targeting microbial biofilms: current and prospective therapeutic strategies
H Koo, RN Allan, RP Howlin, P Stoodley… - Nature Reviews …, 2017 - nature.com
Biofilm formation is a key virulence factor for a wide range of microorganisms that cause
chronic infections. The multifactorial nature of biofilm development and drug tolerance …
chronic infections. The multifactorial nature of biofilm development and drug tolerance …
Beneficial applications of biofilms
LA Philipp, K Bühler, R Ulber, J Gescher - Nature Reviews Microbiology, 2023 - nature.com
Many microorganisms live in the form of a biofilm. Although they are feared in the medical
sector, biofilms that are composed of non-pathogenic organisms can be highly beneficial in …
sector, biofilms that are composed of non-pathogenic organisms can be highly beneficial in …
Biofilms: Survival and defense strategy for pathogens
A Kumar, A Alam, M Rani, NZ Ehtesham… - International Journal of …, 2017 - Elsevier
Studies on biofilm related infections are gaining prominence owing to their involvement in
majority of clinical infections. Biofilm, considered as a generic mechanism for survival used …
majority of clinical infections. Biofilm, considered as a generic mechanism for survival used …
Strategies for antimicrobial drug delivery to biofilm
C Martin, W LiLow, A Gupta… - Current …, 2015 - ingentaconnect.com
Biofilms are formed by the attachment of single or mixed microbial communities to a variety
of biological and/or synthetic surfaces. Biofilm micro-organisms benefit from many …
of biological and/or synthetic surfaces. Biofilm micro-organisms benefit from many …
[HTML][HTML] Combination therapies for biofilm inhibition and eradication: a comparative review of laboratory and preclinical studies
S Hawas, AD Verderosa, M Totsika - Frontiers in cellular and infection …, 2022 - frontiersin.org
Microbial biofilms are becoming increasingly difficult to treat in the medical setting due to
their intrinsic resistance to antibiotics. To combat this, several biofilm dispersal agents are …
their intrinsic resistance to antibiotics. To combat this, several biofilm dispersal agents are …
Novel approaches to combat bacterial biofilms
Highlights•Currently used antibiotics were developed to target planktonic bacteria.•Recent
discoveries on biofilm properties led to promising anti-biofilm strategies.•Biofilm inhibition …
discoveries on biofilm properties led to promising anti-biofilm strategies.•Biofilm inhibition …
[HTML][HTML] Combating bacterial biofilms: current and emerging antibiofilm strategies for treating persistent infections
AG Abdelhamid, AE Yousef - Antibiotics, 2023 - mdpi.com
Biofilms are intricate multicellular structures created by microorganisms on living (biotic) or
nonliving (abiotic) surfaces. Medically, biofilms often lead to persistent infections, increased …
nonliving (abiotic) surfaces. Medically, biofilms often lead to persistent infections, increased …
Applying insights from biofilm biology to drug development—can a new approach be developed?
Most of the research on bacterial pathogenesis has focused on acute infections, but much
less is known about the pathogenesis of infections caused by bacteria that grow as …
less is known about the pathogenesis of infections caused by bacteria that grow as …