Anti-inflammatory activity of low molecular weight polysialic acid on human macrophages
A Shahraz, J Kopatz, R Mathy, J Kappler, D Winter… - Scientific reports, 2015 - nature.com
Oligosialic and polysialic acid (oligoSia and polySia) of the glycocalyx of neural and immune
cells are linear chains, in which the sialic acid monomers are α2. 8-glycosidically linked …
cells are linear chains, in which the sialic acid monomers are α2. 8-glycosidically linked …
Low molecular weight polysialic acid prevents lipopolysaccharide‐induced inflammatory dopaminergic neurodegeneration in humanized SIGLEC11 transgenic mice
H Liao, J Winkler, J Wißfeld, A Shahraz, C Klaus… - Glia, 2021 - Wiley Online Library
Parkinson's disease is one of the most common neurodegenerative diseases in the elderly
population, with a pathophysiology linked to neuroinflammation, complement activation, and …
population, with a pathophysiology linked to neuroinflammation, complement activation, and …
Changes in polysialic acid expression on myeloid cells during differentiation and recruitment to sites of inflammation: role in phagocytosis
NM Stamatos, L Zhang, A Jokilammi, J Finne… - …, 2014 - academic.oup.com
Polysialic acid (polySia) is a unique linear homopolymer of α2, 8-linked sialic acid that has
been studied extensively as a posttranslational modification of neural cell adhesion …
been studied extensively as a posttranslational modification of neural cell adhesion …
Polysialic acid promotes remyelination in cerebellar slice cultures by Siglec-E-dependent modulation of microglia polarization
LJ Schröder, H Thiesler, L Gretenkort… - Frontiers in Cellular …, 2023 - frontiersin.org
Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system.
Spontaneous restoration of myelin after demyelination occurs, but its efficiency declines …
Spontaneous restoration of myelin after demyelination occurs, but its efficiency declines …
Polysialylation and lipopolysaccharide‐induced shedding of E‐selectin ligand‐1 and neuropilin‐2 by microglia and THP‐1 macrophages
S Werneburg, FFR Buettner, L Erben, M Mathews… - Glia, 2016 - Wiley Online Library
Microglia are tissue macrophages and mediators of innate immune responses in the brain.
The protein‐modifying glycan polysialic acid (polySia) is implicated in modulating microglia …
The protein‐modifying glycan polysialic acid (polySia) is implicated in modulating microglia …
Human-specific microglial Siglec-11 transcript variant has the potential to affect polysialic acid-mediated brain functions at a distance
CD33-related Siglecs are often found on innate immune cells and modulate their reactivity
by recognition of sialic acid-based “self-associated molecular patterns” and signaling via …
by recognition of sialic acid-based “self-associated molecular patterns” and signaling via …
Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses
PM Drake, JK Nathan, CM Stock, PV Chang… - The Journal of …, 2008 - journals.aai.org
Polysialic acid (polySia) is a large glycan with restricted expression, typically found attached
to the protein scaffold neural cell adhesion molecule (NCAM). PolySia is best known for its …
to the protein scaffold neural cell adhesion molecule (NCAM). PolySia is best known for its …
Polysialic acid in the immune system
TM Villanueva-Cabello… - Frontiers in …, 2022 - frontiersin.org
Polysialic acid (polySia) is a highly regulated polymer of sialic acid (Sia) with such potent
biophysical characteristics that when expressed drastically influences the interaction …
biophysical characteristics that when expressed drastically influences the interaction …
Alleviation of neurotoxicity by microglial human Siglec-11
Y Wang, H Neumann - Journal of Neuroscience, 2010 - Soc Neuroscience
Sialic acid-binding Ig superfamily lectins (Siglecs) are members of the Ig superfamily that
recognize sialic acid residues of glycoproteins. Siglec-11 is a recently identified human …
recognize sialic acid residues of glycoproteins. Siglec-11 is a recently identified human …
Polysialic acid on SynCAM 1 in NG2 cells and on neuropilin‐2 in microglia is confined to intracellular pools that are rapidly depleted upon stimulation
NG2 cells comprise a heterogeneous precursor population but molecular markers
distinguishing between the assumed NG2 cell subpopulations are lacking. Previously, we …
distinguishing between the assumed NG2 cell subpopulations are lacking. Previously, we …