Background: Iodide uptake at the basolateral membrane and iodide efflux at the apical
membrane of thyrocytes, essential steps in the biosynthesis of thyroid hormone, are …

Pendred's syndrome is an autosomal-recessive disorder characterized by deafness and
goiter. After our recent identification of the human gene mutated in Pendred's syndrome …

Pendrin (SLC26A4), a Cl−/anion exchanger, is expressed at high levels in kidney, thyroid,
and inner ear epithelia, where it has an essential role in bicarbonate secretion/chloride …

A key function of the proximal tubule is retrieval of most of the vast quantities of NaCl and
water filtered by the kidney. Physiological studies using brush border vesicles and perfused …

Pendrin is expressed in the apical regions of type B and non-A, non-B intercalated cells,
where it mediates Cl− absorption and HCO3− secretion through apical Cl−/HCO3 …

Enlargement of the vestibular aqueduct (EVA) is a common inner ear malformation found in
children with sensorineural hearing loss that is frequently associated with loss-of-function or …

The disease gene for Pendred syndrome has been recently characterized and named PDS.
It codes for a transmembrane protein called pendrin, which is highly expressed at the apical …

Mutations in the anion exchanger pendrin are responsible for Pendred syndrome, an
autosomal recessive disease characterized by deafness and goitre. Pendrin is highly …

A significant fraction of active chloride reabsorption across the apical membrane of the
proximal tubule is mediated by a chloride/formate exchange process, whereby intracellular …

Pendred syndrome is the most common form of syndromic deafness, characterized by
dyshormonogenic goiter associated with sensory-neural deafness. The gene responsible for …