Cathepsin C, an important lysosomal cysteine protease, mediates the maturation process of
neutrophil serine proteases, and participates in the inflammation and immune regulation …

Cathepsin C (Cat C) participates in inflammation and immune regulation by affecting the
activation of neutrophil serine proteases (NSPs). Therefore, cathepsin C is an attractive …

Introduction: Cathepsin G (CatG) is a neutral proteinase originating from human neutrophils.
It displays a unique dual specificity (trypsin-and chymotrypsin-like); thus, its enzymatic …

Introduction: Cathepsins play an important role in protein degradation and processing.
Aberrant cathepsin B or L is closely associated with many serious diseases such as cancer …

Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate | Journal
of Medicinal Chemistry ACS ACS Publications C&EN CAS Find my institution Log In Journal of …

Cathepsin S is one of the major cysteine proteases, and is expressed in the lysosome of
antigen presenting cells; primarily dendritic cells, B-cells and macrophages. Cathepsin S is …

The widespread coronavirus SARS-CoV-2 has already infected over 4 million people
worldwide, with a death toll over 280,000. Current treatment of COVID-19 patients relies …

Importance to the field: Cathepsin C (dipeptidyl peptidase I) plays a key role in the activation
of several degradative enzymes linked to tissue destruction in inflammatory diseases. Thus …

The discovery of potent and selective cyanamide-based inhibitors of the cysteine protease
cathepsin C is detailed. Optimization of the template with regard to plasma stability led to the …

Human cathepsin L belongs to the cathepsin family of proteolytic enzymes with primarily an
endopeptidase activity. Although its primary functions were originally thought to be only of a …