Liver cancer oncogenomics: opportunities and dilemmas for clinical applications

JU Marquardt, JB Andersen - Hepatic oncology, 2015 - Taylor & Francis
Primary liver cancers are among the most rapidly evolving malignant tumors worldwide. An
underlying chronic inflammatory liver disease, which precedes liver cancer development for …

Understanding Gene Involvement in Hepatocellular Carcinoma: Implications for Gene Therapy and Personalized Medicine

MA Younis, H Harashima - Pharmacogenomics and Personalized …, 2024 - Taylor & Francis
Hepatocellular carcinoma (HCC) is the dominant type of liver cancers and is one of the
deadliest health threats globally. The conventional therapeutic options for HCC are …

Molecular profiling of liver tumors: classification and clinical translation for decision making

R Pinyol, JC Nault, IM Quetglas… - Seminars in liver …, 2014 - thieme-connect.com
Hepatocellular carcinoma (HCC) is a complex disease with a dismal prognosis.
Consequently, a translational approach is required to personalized clinical decision making …

[图书][B] Molecular genetics of liver neoplasia

XW Wang, JW Grisham, SS Thorgeirsson - 2011 - Springer
Primary liver cancer is the third most deadly and fifth most common cancer worldwide, with
an estimated 877,000 new cases and almost as many deaths in 2007. Hepatocellular …

Epigenetics of hepatocellular carcinoma

TB Toh, JJ Lim, EKH Chow - Clinical and translational medicine, 2019 - Springer
In recent years, large scale genomics and genome-wide studies using comprehensive
genomic tools have reshaped our understanding of cancer evolution and heterogeneity …

Genomics in hepatocellular carcinoma—a big step forward

R Tateishi, M Omata - Nature reviews Gastroenterology & hepatology, 2012 - nature.com
Despite enthusiastic efforts using the latest advanced molecular technologies, no specific
universal genetic alteration has been found in hepatocellular carcinoma (HCC). The …

[HTML][HTML] Cancer gene discovery in hepatocellular carcinoma

L Zender, A Villanueva, V Tovar, D Sia, DY Chiang… - Journal of …, 2010 - Elsevier
Hepatocellular carcinoma (HCC) is a deadly cancer, whose incidence is increasing
worldwide. Albeit the main risk factors for HCC development have been clearly identified …

Functional genomic studies: insights into the pathogenesis of liver cancer

ZG Han - Annual review of genomics and human genetics, 2012 - annualreviews.org
Liver cancer is the sixth-most-common cancer overall but the third-most-frequent cause of
cancer death. Among primary liver cancers, hepatocellular carcinoma (HCC), the major …

Genetic biomarkers for hepatocellular carcinoma in the era of precision medicine

J Duan, Y Wu, J Liu, J Zhang, Z Fu, T Feng… - Journal of …, 2019 - Taylor & Francis
Being one of the most lethal cancers that exhibit high levels of heterogeneity, hepatocellular
carcinoma (HCC) is associated with diverse oncogenic pathways underpinned by varied …

Hepatocellular carcinoma: towards personalized medicine

D Miki, H Ochi, CN Hayes, H Aikata… - Cancer science, 2012 - Wiley Online Library
Over the past several years, the success of genome‐wide association studies (GWAS) and
pharmacogenomics has gradually begun to enable personalized medicine in some fields. In …