Integrin-mediated cell adhesions provide dynamic, bidirectional links between the
extracellular matrix and the cytoskeleton. Besides having central roles in cell migration and …

Matrix mechanics controls cell fate by modulating the bonds between integrins and
extracellular matrix (ECM) proteins. However, it remains unclear how fibronectin (FN), type 1 …

Integrin adhesions assemble and mature in response to ligand binding and mechanical
factors, but the molecular-level organization is not known. We report that∼ 100-nm clusters …

We have characterized early steps of α2β1 integrin-mediated cell adhesion to a collagen
type I matrix by using single-cell force spectroscopy. In agreement with the role of α2β1 as a …

During cell migration, the forces generated in the actin cytoskeleton are transmitted across
transmembrane receptors to the extracellular matrix or other cells through a series of …

To survive in a mechanically active environment, cells must adapt to variations of applied
membrane tension. A collagen-coated magnetic bead model was used to apply forces …

Many essential cellular functions in health and disease are closely linked to the ability of
cells to respond to mechanical forces. In the context of cell adhesion to the extracellular …

Integrin-dependent cell adhesions come in different shapes and serve in different cell types
for tasks ranging from cell-adhesion, migration, and the remodeling of the extracellular …

Force transmission at integrin-based adhesions is important for cell migration and
mechanosensing. Talin is an essential focal adhesion (FA) protein that links F-actin to …

Forces transmitted by integrins regulate many important cellular functions. Previously, we
developed tension gauge tether (TGT) as a molecular force sensor and determined the …