Binding of integrin receptors to extracellular ligands is a complex process involving receptor-
ligand interactions at the cell-substrate interface, signals activating the receptors, and …

The β subunit cytoplasmic domains of integrin adhesion receptors are necessary for the
connection of these receptors to the actin cytoskeleton. The cytoplasmic protein, talin, binds …

As adhesion molecules, integrins connect a cell to its environment and transduce signals
across the membrane. Their different functional states correspond to distinct conformations …

Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

Adhesion-dependent cells actively sense the mechanical properties of their environment
through mechanotransductory processes at focal adhesions, which are integrin-based …

Cell spreading, adhesion and remodelling of the extracellular matrix (ECM) involve bi-
directional signalling and physical linkages between the ECM, integrins and the cell …

Integrins bind extracellular matrix fibrils and associate with intracellular actin filaments
through a variety of cytoskeletal linker proteins to mechanically connect intracellular and …

Integrins undergo large-scale conformational changes upon activation. Signaling events
driving integrin activation have previously been discussed conceptually, but not …

Mechanical forces play a major role in the regulation of cell adhesion and cytoskeletal
organization. In order to explore the molecular mechanism underlying this regulation, we …

Background Cells sense the extracellular environment using adhesion receptors (integrins)
linked to the intracellular actin cytoskeleton through a complex network of regulatory …