The material properties of a cell determine how mechanical forces are transmitted through
and sensed by that cell. Some types of cells stiffen passively under large external forces, but …

Integrins undergo large-scale conformational changes upon activation. Signaling events
driving integrin activation have previously been discussed conceptually, but not …

Mechanotransduction is a critical function for cells, in terms of cell viability, shaping of
tissues, and cellular behavior. In vitro, cellular level forces can stretch adhesion proteins that …

Adhesion-mediated signaling provides cells with information about multiple parameters of
their microenvironment, including mechanical characteristics. Often, such signaling is based …

Integrins are adhesion receptors that transmit force across the plasma membrane between
extracellular ligands and the actin cytoskeleton. In activation of the transforming growth …

Position-dependent cycling of integrin interactions with both the cytoskeleton and
extracellular matrix (ECM) is essential for cell spreading, migration, and wound healing …

Cells undergo dynamic remodeling of the cytoskeleton during adhesion and migration on
various extracellular matrix (ECM) substrates in response to physiological and pathological …

Cell adhesion to extracellular matrix components involves integrin receptor-ligand binding
and adhesion strengthening, comprising receptor clustering, cytoskeletal interactions, and …

Integrin-extracellular matrix (ECM) interactions in two-dimensional (2D) culture systems are
widely studied (Goldstein and DiMilla, 2002. J Biomed. Mater. Res. 59, 665–675; Koo et al …

The ability of integrin adhesion receptors to undergo rapid changes in affinity for their
extracellular ligands (integrin activation) is essential for the development and function of …