Payload distribution and capacity of mRNA lipid nanoparticles
Lipid nanoparticles (LNPs) are effective vehicles to deliver mRNA vaccines and
therapeutics. It has been challenging to assess mRNA packaging characteristics in LNPs …
therapeutics. It has been challenging to assess mRNA packaging characteristics in LNPs …
Development of a high-throughput platform for screening lipid nanoparticles for mRNA delivery
L Cui, S Pereira, S Sonzini, S van Pelt, SM Romanelli… - Nanoscale, 2022 - pubs.rsc.org
mRNA lipid nanoparticles (LNPs) are at the forefront of nucleic acid intracellular delivery, as
exemplified by the recent emergency approval of two mRNA LNP-based COVID-19 …
exemplified by the recent emergency approval of two mRNA LNP-based COVID-19 …
Deconvoluting lipid nanoparticle structure for messenger RNA delivery
Lipid nanoparticle (LNP) packaged mRNA vaccines have been deployed against infectious
diseases such as COVID-19, yet their structural features remain unclear. Cholesterol, a …
diseases such as COVID-19, yet their structural features remain unclear. Cholesterol, a …
Testing the in vitro and in vivo efficiency of mRNA-lipid nanoparticles formulated by microfluidic mixing
Lipid nanoparticles (LNPs) have attracted widespread attention recently with the successful
development of the COVID-19 mRNA vaccines by Moderna and Pfizer/BioNTech. These …
development of the COVID-19 mRNA vaccines by Moderna and Pfizer/BioNTech. These …
Elucidation of lipid nanoparticle surface structure in mRNA vaccines
Lipid nanoparticles (LNPs) have been used as a carrier for messenger RNA (mRNA)
vaccines. Surface properties of LNPs are important to the stability and function of mRNA …
vaccines. Surface properties of LNPs are important to the stability and function of mRNA …
The role of lipid components in lipid nanoparticles for vaccines and gene therapy
CH Albertsen, JA Kulkarni, D Witzigmann… - Advanced drug delivery …, 2022 - Elsevier
Lipid nanoparticles (LNPs) play an important role in mRNA vaccines against COVID-19. In
addition, many preclinical and clinical studies, including the siRNA-LNP product, Onpattro® …
addition, many preclinical and clinical studies, including the siRNA-LNP product, Onpattro® …
A careful look at lipid nanoparticle characterization: analysis of benchmark formulations for encapsulation of RNA cargo size gradient
With the recent success of lipid nanoparticle (LNP) based SARS-CoV-2 mRNA vaccines, the
potential for RNA therapeutics has gained widespread attention. LNPs are promising non …
potential for RNA therapeutics has gained widespread attention. LNPs are promising non …
Mechanistic studies of an automated lipid nanoparticle reveal critical pharmaceutical properties associated with enhanced mRNA functional delivery in vitro and in …
Recently, lipid nanoparticles (LNPs) have attracted attention due to their emergent use for
COVID‐19 mRNA vaccines. The success of LNPs can be attributed to ionizable lipids, which …
COVID‐19 mRNA vaccines. The success of LNPs can be attributed to ionizable lipids, which …
[HTML][HTML] Impact of lipid nanoparticle size on mRNA vaccine immunogenicity
KJ Hassett, J Higgins, A Woods, B Levy, Y Xia… - Journal of Controlled …, 2021 - Elsevier
Lipid nanoparticles (LNP) are effective delivery vehicles for messenger RNA (mRNA) and
have shown promise for vaccine applications. Yet there are no published reports detailing …
have shown promise for vaccine applications. Yet there are no published reports detailing …
Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening
PPG Guimaraes, R Zhang, R Spektor, M Tan… - Journal of Controlled …, 2019 - Elsevier
Messenger RNA (mRNA) has recently emerged as a promising class of nucleic acid therapy,
with the potential to induce protein production to treat and prevent a range of diseases …
with the potential to induce protein production to treat and prevent a range of diseases …