Cyclin dependent kinase 5 (CDK5) is a serine/threonine kinase belonging to the cyclin
dependent kinase (CDK) family. CDK5 is involved in numerous neuronal diseases …

Abstract Cyclin-dependent kinase 5 (CDK5) is the serine/threonine-directed kinase mainly
found in the brain and plays a significant role in developing the central nervous system …

Here is described a structural model for the binary complex CDK5–roscovitine. Roscovitine
has been shown to potently inhibit cyclin-dependent kinases 1, 2 and 5 (CDK1, 2, and 5) …

Cyclin-dependent kinase 5 (CDK5) is a serine/threonine protein kinase and its deregulation
is implicated in a number of neurodegenerative disorders such as Alzheimer's disease …

The cyclin-dependent kinases (CDK) CDK1, CDK2, CDK4, and CDK6 are serine/threonine
protein kinases targeted in cancer therapy due to their role in cell cycle progression. The …

Purine inhibitors of cyclin-dependent kinases attract attention as potential anticancer drugs
because their first representative roscovitine recently entered clinical trials. Although well …

Cyclin-dependent kinases (CDKs) and casein kinases 1 (CK1) are involved in the two key
molecular features of Alzheimer's disease, production of amyloid-β peptides (extracellular …

Abstract Cyclin-dependent kinase 5 (CDK5) and Casein kinase 1 (CK1) are both involved in
the hyperphosphorylation of the Tau protein and in the amyloid-β production, the two major …

Cyclin-dependent kinase 5 (CDK5) is a serine/threonine kinase that plays a critical role in
the early development of the nervous system. Deregulation of CDK5 is believed to contribute …

Small molecular inhibitors of Cyclin dependent kinases (Cdks) are currently being
developed as anticancer therapeutics due to their antiproliferative properties. The purine …