Many years ago, alert observers noticed among thousands of laboratory mice a few
individuals that, unlike their littermates, exhibited areas of white spotting on their fur. No one …

Interactions between products of the mouse W locus, which encodes the c-kit tyrosine kinase
receptor, and the Sl locus, which encodes a ligand for c-kit receptor, which we have …

Mast cell development is a complex process that results in the appearance of phenotypically
distinct populations of mast cells in different anatomical sites. Mice homozygous for …

Stem cell factor (SCF), the ligand for the receptor (SCFR) that is encoded by the c-kit proto-
oncogene, has many important effects in mouse and human mast cell development, survival …

The receptor tyrosine kinase c-Kit and its ligand Stem Cell Factor (SCF) are essential for
haemopoiesis, melanogenesis and fertility. SCF acts at multiple levels of the haemopoietic …

Stem cell factor (SCF) and its receptor (SCFR), a member of the receptor tyrosine kinase III
family that is encoded by the c-kit gene, critically regulate several complex biological …

Publisher Summary This chapter focuses on the importance of stem cell factor (SCF) and the
stem cell factor receptor (SCFR) in hematopoiesis and other complex developmental …

We investigated the effects of a newly recognized multifunctional growth factor, the c-kit
ligand stem cell factor (SCF), on mouse mast cell proliferation and phenotype. Recombinant …

The murine Wand Steel loci encode the Kit receptor tyrosine kinase and its ligand, Steel
factor, respectively. Loss of function mutations at either the W or Sl loci lead to a variety of …

Mast cells accumulate at sites of neovascularization, solid tumors, and many immune
reactions. Such accumulation requires directed migration of mature mast cells or their …