Radiosensitizing effect of bromelain using tumor mice model via Ki-67 and PARP-1 inhibition

MH Mekkawy, HA Fahmy, AS Nada… - Integrative Cancer …, 2021 - journals.sagepub.com
Recent reports have shown that bromelain (BL), a pineapple extract, acts as an adjuvant
therapy in cancer treatment and prevention of carcinogenesis. The present study was …

Study of the radiosensitizing and radioprotective efficacy of bromelain (a pineapple extract): in vitro and in vivo

MH Mekkawy, HA Fahmy, AS Nada… - Integrative Cancer …, 2020 - journals.sagepub.com
This study hypothesizes that, bromelain (BL) acts as radiosensitizer of tumor cells and that it
protects normal cells from radiation effects. In vitro and in vivo studies have been carried out …

Evaluation of the radiosensitizing potency of bromelain for radiation therapy of 4T1 breast cancer cells

F Raeisi, D Shahbazi-Gahrouei, E Raeisi… - Journal of Medical …, 2019 - journals.lww.com
Breast cancer (BC) remains the leading cause of death in women worldwide, despite the
improvements of cancer screening and treatment methods. Recently, development of novel …

Cytotoxic effects of bromelain in human gastrointestinal carcinoma cell lines (MKN45, KATO-III, HT29-5F12, and HT29-5M21)

A Amini, A Ehteda, S Masoumi Moghaddam… - OncoTargets and …, 2013 - Taylor & Francis
Background Bromelain is a pineapple stem extract with a variety of therapeutic benefits
arising from interaction with a number of different biological processes. Several preclinical …

In vitro and in vivo superior radiosensitizing effect of berbamine for head and neck squamous cell carcinoma

H Zhu, S Ruan, F Jia, J Chu, Y Zhu… - OncoTargets and …, 2018 - Taylor & Francis
Background Berbamine (BBM), one of the bis-benzylisoquinoline products isolated from
Berberis amurensis, has been demonstrated for its anticancer effect against leukemia …

[HTML][HTML] Berberine enhances the sensitivity of radiotherapy in ovarian cancer cell line (SKOV-3)

MS Aleissa, ALZ Mohammed, LM Alneghery… - Saudi Pharmaceutical …, 2023 - Elsevier
Berberine, a well-known isoquinoline alkaloid derivative, has a varied range of
pharmacological effects. Herein, we notice the radio-modulatory outcome of berberine in …

[HTML][HTML] Radio-sensitizing effect of a cocktail of phytochemicals on HepG2 cell proliferation, motility and survival

ME Abdraboh, ZS Essa, AB Abdelrazzak… - Biomedicine & …, 2020 - Elsevier
Radio-resistance is a major hurdle challenging oncologist worldwide. Despite their anti-
cancer characteristics, the implication of phytochemicals in clinical trials is still limited. This …

[HTML][HTML] Berberine enhances the radiosensitivity of hepatoma cells by Nrf2 pathway

X You, X Cao, Y Lin - Frontiers in Bioscience-Landmark, 2019 - imrpress.com
Radiation therapy is a major treatment in hepatocellular carcinoma (HCC). Yet, this
treatment is ineffective in HCC due to lack of radiosensitivity. For this reason, we examined …

Bromelain's activity and potential as an anti-cancer agent: current evidence and perspectives

K Chobotova, AB Vernallis, FAA Majid - Cancer letters, 2010 - Elsevier
The medicinal qualities of pineapple are recognized in many traditions in South America,
China and Southeast Asia. These qualities are attributed to bromelain, a 95%-mixture of …

[PDF][PDF] Bromelain as a potential material in future chemotherapy: A review

SM Noor, R Roslan, SC Fhong… - Int. J. Eng. Technol. Manag …, 2022 - tuengr.com
Cancer is an uncontrolled cell growth-type chronic illness. It is usually associated with
oxidative stress and chronic inflammation. Pineapple and its components have been shown …