Pancreatic islet hepatocyte growth factor and vascular endothelial growth factor A signaling in growth restricted fetuses
PJ Rozance, WW Hay Jr - Molecular and cellular endocrinology, 2016 - Elsevier
Placental insufficiency leads to intrauterine growth restriction (IUGR) and a lifelong risk of
developing type 2 diabetes. Impaired islet development in the growth restricted fetus …
developing type 2 diabetes. Impaired islet development in the growth restricted fetus …
The impact of IUGR on pancreatic islet development and β-cell function
BH Boehmer, SW Limesand… - Journal of …, 2017 - joe.bioscientifica.com
Placental insufficiency is a primary cause of intrauterine growth restriction (IUGR). IUGR
increases the risk of developing type 2 diabetes mellitus (T2DM) throughout life, which …
increases the risk of developing type 2 diabetes mellitus (T2DM) throughout life, which …
Placental insufficiency decreases pancreatic vascularity and disrupts hepatocyte growth factor signaling in the pancreatic islet endothelial cell in fetal sheep
PJ Rozance, M Anderson, M Martinez, A Fahy… - Diabetes, 2015 - Am Diabetes Assoc
Hepatocyte growth factor (HGF) and vascular endothelial growth factor A (VEGFA) are
paracrine hormones that mediate communication between pancreatic islet endothelial cells …
paracrine hormones that mediate communication between pancreatic islet endothelial cells …
Prenatal programming of insulin secretion in intrauterine growth restriction
KL Gatford, RA Simmons - Clinical obstetrics and gynecology, 2013 - journals.lww.com
Intrauterine growth restriction (IUGR) impairs insulin secretion in humans and in animal
models of IUGR. Several underlying mechanisms have been implicated, including …
models of IUGR. Several underlying mechanisms have been implicated, including …
Insulin-like growth factor and fibroblast growth factor expression profiles in growth-restricted fetal sheep pancreas
X Chen, PJ Rozance, WW Hay Jr… - … Biology and Medicine, 2012 - journals.sagepub.com
Placental insufficiency results in intrauterine growth restriction (IUGR), impaired fetal insulin
secretion and less fetal pancreatic β-cell mass, partly due to lower β-cell proliferation rates …
secretion and less fetal pancreatic β-cell mass, partly due to lower β-cell proliferation rates …
Placental programming of postnatal diabetes and impaired insulin action after IUGR
KL Gatford, RA Simmons, MJ De Blasio, JS Robinson… - Placenta, 2010 - Elsevier
Being born small due to poor growth before birth increases the risk of developing metabolic
disease, including type 2 diabetes, in later life. Inadequate insulin secretion and decreasing …
disease, including type 2 diabetes, in later life. Inadequate insulin secretion and decreasing …
Role of placental insufficiency and intrauterine growth restriction on the activation of fetal hepatic glucose production
SR Wesolowski, WW Hay Jr - Molecular and cellular endocrinology, 2016 - Elsevier
Glucose is the major fuel for fetal oxidative metabolism. A positive maternal–fetal glucose
gradient drives glucose across the placenta and is sufficient to meet the demands of the …
gradient drives glucose across the placenta and is sufficient to meet the demands of the …
Maternal diabetes impairs insulin and IGF-1 receptor expression and signaling in human placenta
A Tumminia, NM Scalisi, A Milluzzo, G Ettore… - Frontiers in …, 2021 - frontiersin.org
Background Maternal high blood glucose during pregnancy increases the risk for both
maternal and fetal adverse outcomes. The mechanisms underlying the regulator effects of …
maternal and fetal adverse outcomes. The mechanisms underlying the regulator effects of …
Maternal‐placental insulin‐like growth factor (IGF) signaling and its importance to normal embryo‐fetal development
CJ Bowman, RD Streck… - Birth Defects Research Part …, 2010 - Wiley Online Library
As background for an antibody‐based therapeutic program against the IGF receptor, we
undertook a review of available information on the early pregnancy‐specific regulation and …
undertook a review of available information on the early pregnancy‐specific regulation and …
Placental growth hormone, fetal growth and the IGF axis in normal and diabetic pregnancy
HD McIntyre, W Zeck, A Russell - Current diabetes reviews, 2009 - ingentaconnect.com
Gestational diabetes mellitus (GDM) and pre-gestational diabetes are known to pose risks to
the mother and developing fetus, often related to abnormal fetal growth. One potential …
the mother and developing fetus, often related to abnormal fetal growth. One potential …