Cellular and molecular mediators of neuroinflammation in the pathogenesis of Parkinson's disease

SV More, H Kumar, IS Kim, SY Song… - Mediators of …, 2013 - Wiley Online Library
Neuroinflammation is a host‐defense mechanism associated with restoration of normal
structure and function of the brain and neutralization of an insult. Increasing …

Neuroinflammation, oxidative stress, and the pathogenesis of Parkinson's disease

RL Mosley, EJ Benner, I Kadiu, M Thomas… - Clinical neuroscience …, 2006 - Elsevier
Neuroinflammatory processes play a significant role in the pathogenesis of Parkinson's
disease (PD). Epidemiologic, animal, human, and therapeutic studies all support the …

The role of inflammatory and oxidative stress mechanisms in the pathogenesis of Parkinson's disease: focus on astrocytes

R Niranjan - Molecular neurobiology, 2014 - Springer
Neuroinflammation plays a key role in the pathogenesis of Parkinson's disease (PD).
Epidemiologic, animal, human, and therapeutic studies support the role of oxidative stress …

Microglia mediated neuroinflammation in Parkinson's disease

S Isik, B Yeman Kiyak, R Akbayir, R Seyhali, T Arpaci - Cells, 2023 - mdpi.com
Parkinson's Disease (PD) is the second most common neurodegenerative disorder seen,
especially in the elderly. Tremor, shaking, movement problems, and difficulty with balance …

Inflammation in Parkinson's disease

KU Tufekci, R Meuwissen, S Genc, K Genc - Advances in protein chemistry …, 2012 - Elsevier
Parkinson's disease (PD) is a common neurodegenerative disease that is characterized by
the degeneration of dopaminergic neurons in the substantia nigra pars compacta …

Neurodegeneration and inflammation—an interesting interplay in Parkinson's disease

C Marogianni, M Sokratous, E Dardiotis… - International journal of …, 2020 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disorder, caused by, so far, unknown
pathogenetic mechanisms. There is no doubt that pro-inflammatory immune-mediated …

Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention

MG Tansey, MS Goldberg - Neurobiology of disease, 2010 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disease, after
Alzheimer's disease. The potential causes of PD remain uncertain, but recent studies …

Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease

YS Kim, TH Joh - Experimental & molecular medicine, 2006 - nature.com
Inflammation, a self-defensive reaction against various pathogenic stimuli, may become
harmful self-damaging process. Increasing evidence has linked chronic inflammation to a …

Significant roles of neuroinflammation in Parkinson's disease: therapeutic targets for PD prevention

Y Lee, S Lee, SC Chang, J Lee - Archives of pharmacal research, 2019 - Springer
Glial cells outnumber neurons in the brain and play important roles in the neuroinflammation
that accompanies brain damage in neurodegenerative diseases. In Parkinson's disease …

Neuroinflammation in Parkinson's disease and its potential as therapeutic target

Q Wang, Y Liu, J Zhou - Translational neurodegeneration, 2015 - Springer
Abstract Parkinson's disease (PD), the second most common age-associated
neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and …