Cancer growth and metastasis require the coordinate change in gene expression of different
sets of genes. While genetic alterations can account for some of these changes, it is …

DNA methylation plays an important role in the establishment and maintenance of the
program of gene expression. Tumor cells are characterized by a paradoxical alteration of …

The epigenome, which is comprised of chromatin and its associated proteins and the
patterns of covalent modification of DNA by methylation, sets up and maintains gene …

Cancer growth and metastasis requires reprogramming of the expression of multiple genes.
The epigenome, which is comprised of chromatin and the patterns of DNA methylation, sets …

BACKGROUND Three principal kinds of aberration in the DNA methylation machinery occur
in cancer:• Hypermethylation of tumour suppressor genes5–7• Aberrant expression of DNA …

Epigenetic modifications include DNA methylation and covalent modification of histones.
These alterations are reversible but very stable and exert a significant impact on the …

Despite the recent advances in chemotherapeutic treatments against cancer, some types of
highly aggressive and invasive cancer develop drug resistance against conventional …

DNA methylation is one of the most intensely studied epigenetic modifications in mammals.
In normal cells, it assures the proper regulation of gene expression and stable gene …

DNA methylation is a significant regulator of gene expression, and its role in carcinogenesis
recently has been a subject of remarkable interest. The aim of this review is to analyze the …

DNA methylation is one among the major grounds of cancer progression which is
characterized by the addition of a methyl group to the promoter region of the gene thereby …