The endoplasmic reticulum (ER) is the site of folding of membrane and secreted proteins in
the cell. Physiological or pathological processes that disturb protein folding in the …

The endoplasmic reticulum (ER) functions to properly fold and process secreted and
transmembrane proteins. Environmental and genetic factors that disrupt ER function cause …

The endoplasmic reticulum (ER) is the cell organelle where secretory and membrane
proteins are synthesized and folded. Correctly folded proteins exit the ER and are …

The extensive membrane network of the endoplasmic reticulum (ER) is physically
juxtaposed to and functionally entwined with essentially all other cellular compartments …

In all eukaryotic cells, the endoplasmic reticulum (ER) is an intracellular organelle where
folding and assembly occurs for proteins destined to the extracellular space, plasma …

The accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER)
induces a coordinated adaptive program called the unfolded protein response (UPR). The …

Cells respond to the accumulation of unfolded proteins by activating signal transduction
cascades that improve protein folding. One example of such a cascade is the unfolded …

The endoplasmic reticulum (ER) is the site of synthesis and folding of membrane and
secretory proteins, which, collectively, represent a large fraction of the total protein output of …

Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …

The endoplasmic reticulum (ER) is the site where proteins enter the secretory pathway.
Proteins are translocated into the ER lumen in an unfolded state and require protein …