Glioblastomas, the most common form of primary brain tumors, are the fourth cause of death
by cancer in adults. Increasing evidences suggest that glioblastoma resistance to existing …

Resveratrol prolongs lifespan and prevent cancer formation; however, the mechanisms are
not understood. Here we evaluated the cell-cycle inhibition and apoptosis of resveratrol in …

Background/Aim: Sirtuins (SIRTs) play crucial roles in various signaling pathways that
modulate differentiation and proliferation. We sought to elucidate the role of SIRTs in …

Abstract Sirtuin‐1 and‐3 (SIRT1 and SIRT3) are important nicotinamide adenine
dinucleotide (NAD+)‐dependent deacetylases known to regulate a variety of cellular …

Malignant glioma is one of the most common types of primary malignancies in the human
central nervous system. Temozolomide (TMZ) is the most commonly used drug in clinical …

Abstract Sirtuin 6 (SIRT6) is a member of the mammalian NAD+‑dependent deacetylase
sirtuin family that acts to maintain genomic stability and to repress genes. SIRT6 has recently …

Chondrosarcoma is a malignant primary bone tumor. Sirtuin-1 (SIRT1), which is a member
of sirtuin family, plays a dual role either in cancer promotion or suppression. There is no …

Sirtuins regulate several processes associated with tumor development. Resveratrol was
shown to stimulate sirtuin 1 and 3 (SIRT1/3) activities and to result in cytotoxicity for some …

Abstract Sirtuin-1 (Sirt-1), an NAD-dependent deacetylase, promotes tumorigenesis in
glioma; however, whether the Sirt-1 specific inhibitor, EX527 exerts antitumor effects and the …

Sirtuins are NAD+-dependent deacetylases that regulate numerous cellular processes
including aging, DNA repair, cell cycle, metabolism, and survival under stress conditions …