Seasonal affective disorder (SAD), beyond mood changes, is characterized by alterations in
daily rhythms of behavior and physiology. The pathophysiological conditions of SAD involve …

The lack of appropriate animal models for affective disorders is a major factor hindering
better understanding of the underlying pathologies and the development of more efficacious …

Despite the common use of bright light exposure for treatment of seasonal affective disorder
(SAD), the underlying biology of the therapeutic effect is not clear. Moreover, there is a …

A possible relationship between circadian rhythms and affective disorders has been strongly
implicated, but understanding of the biological basis of such a relationship demands the …

Circadian disruption is a common by-product of modern life. Although jet lag and shift work
are well-documented challenges to circadian organization, many more subtle environmental …

Besides generating vision, light modulates various physiological functions, including mood.
While light therapy applied in the daytime is known to have anti-depressive properties …

The development of animal models is a critical step for exploring the underlying
pathophysiological mechanisms of major affective disorders and for evaluating potential …

Light has profound effects on mood regulation as exemplified in seasonal affective disorder
(SAD) and the therapeutic benefits of light therapy. However, the underlying neural …

Light is an important environmental factor for regulation of mood. There is a high frequency
of seasonal affective disorder in high latitudes where light exposure is limited, and bright …

Circadian rhythms are strongly implicated in affective disorders and some recent studies
suggested that diurnal rodents might be advantageous model animals for them. In line with …