[HTML][HTML] Therapeutic targets in amyotrophic lateral sclerosis: focus on ion channels and skeletal muscle
N Tarantino, I Canfora, GM Camerino, S Pierno - Cells, 2022 - mdpi.com
Amyotrophic Lateral Sclerosis is a neurodegenerative disease caused by progressive loss
of motor neurons, which severely compromises skeletal muscle function. Evidence shows …
of motor neurons, which severely compromises skeletal muscle function. Evidence shows …
Evidence-based drug treatment in amyotrophic lateral sclerosis and upcoming clinical trials
AC Ludolph, S Jesse - Therapeutic advances in neurological …, 2009 - journals.sagepub.com
Amyotrophic lateral sclerosis/motor neuron disease is a severe neurodegenerative disease
characterized by upper and lower motor neuron degeneration for which there is no truly …
characterized by upper and lower motor neuron degeneration for which there is no truly …
Therapeutic developments in the treatment of amyotrophic lateral sclerosis
M Jackson, J Lladó, JD Rothstein - Expert Opinion on …, 2002 - Taylor & Francis
Amyotrophic lateral sclerosis is a progressive neurodegenerative disease characterised by
the selective death of motor neurons. The mechanisms and processes responsible for the …
the selective death of motor neurons. The mechanisms and processes responsible for the …
[HTML][HTML] Amyotrophic lateral sclerosis: an update for 2013 clinical features, pathophysiology, management and therapeutic trials
PH Gordon - Aging and disease, 2013 - ncbi.nlm.nih.gov
Amyotrophic lateral sclerosis (ALS), first described by Jean-Martin Charcot in the 1870s, is
an age-related disorder that leads to degeneration of motor neurons. The disease begins …
an age-related disorder that leads to degeneration of motor neurons. The disease begins …
Current and prospective disease-modifying therapies for amyotrophic lateral sclerosis
JA Morren, N Galvez-Jimenez - Expert Opinion on Investigational …, 2012 - Taylor & Francis
Introduction: Amyotrophic lateral sclerosis (ALS) is a devastating illness of unclear etiology
affecting motor neurons. It causes unremitting muscle paralysis, atrophy and death usually …
affecting motor neurons. It causes unremitting muscle paralysis, atrophy and death usually …
Emerging drugs for the treatment of amyotrophic lateral sclerosis: a focus on recent phase 2 trials
A Barp, F Gerardi, A Lizio, VA Sansone… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative
disease involving both upper and lower motor neurons and resulting in increasing disability …
disease involving both upper and lower motor neurons and resulting in increasing disability …
Therapies in amyotrophic lateral sclerosis–beyond riluzole
KE Morrison - Current opinion in pharmacology, 2002 - Elsevier
Several mechanisms have been proposed to account for the progressive motor neurone
death evident in amyotrophic lateral sclerosis. These include oxidative stress, neurofilament …
death evident in amyotrophic lateral sclerosis. These include oxidative stress, neurofilament …
Pharmacotherapy for amyotrophic lateral sclerosis: a review of approved and upcoming agents
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder
involving loss of upper and lower motor neurons, with most cases ending in death within 3–5 …
involving loss of upper and lower motor neurons, with most cases ending in death within 3–5 …
The clinical trial landscape in amyotrophic lateral sclerosis—Past, present, and future
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease marked by
progressive loss of muscle function. It is the most common adult‐onset form of motor neuron …
progressive loss of muscle function. It is the most common adult‐onset form of motor neuron …
What skeletal muscle has to say in amyotrophic lateral sclerosis: Implications for therapy
R Manzano, JM Toivonen… - British Journal of …, 2021 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is an adult onset disorder characterized by progressive
neuromuscular junction (NMJ) dismantling and degeneration of motor neurons leading to …
neuromuscular junction (NMJ) dismantling and degeneration of motor neurons leading to …