[HTML][HTML] Cannabidiol affects extracellular vesicle release, miR21 and miR126, and reduces prohibitin protein in glioblastoma multiforme cells

US Kosgodage, P Uysal-Onganer, A MacLatchy… - Translational …, 2019 - Elsevier
Glioblastoma multiforme (GBM) is the most common and aggressive form of primary
malignant brain tumor in adults, with poor prognosis. Extracellular vesicles (EVs) are key …

[HTML][HTML] Cannabidiol (CBD) is a novel inhibitor for exosome and microvesicle (EMV) release in cancer

US Kosgodage, R Mould, AB Henley… - Frontiers in …, 2018 - frontiersin.org
Exosomes and microvesicles (EMV) are lipid bilayer-enclosed structures, released by cells
and involved in intercellular communication through transfer of proteins and genetic …

Inhalant cannabidiol inhibits glioblastoma progression through regulation of tumor microenvironment

H Khodadadi, ÉL Salles, A Alptekin… - Cannabis and …, 2023 - liebertpub.com
Introduction: Glioblastoma (GBM) is the most common invasive brain tumor composed of
diverse cell types with poor prognosis. The highly complex tumor microenvironment (TME) …

Altering biomolecular condensates as a potential mechanism that mediates cannabidiol effect on glioblastoma

LP Wang, PS Chagas, ÉL Salles, SE Naeini, J Gouron… - Medical Oncology, 2024 - Springer
Glioblastoma (GBM) is an extremely aggressive primary brain tumor with poor prognosis,
short survival time post-diagnosis and high recurrence. Currently, no cure for GBM exists …

[HTML][HTML] The cytotoxic effects of cannabidiol and cannabigerol on glioblastoma stem cells may mostly involve GPR55 and TRPV1 signalling

TT Lah, B Majc, M Novak, A Sušnik, B Breznik… - Cancers, 2022 - mdpi.com
Simple Summary In glioblastoma (GBM), the highest-grade IV glioma, members of the large
membrane receptor family of G protein-coupled receptors (GPCRs) are upregulated …

Cannabidiol inhibits RAD51 and sensitizes glioblastoma to temozolomide in multiple orthotopic tumor models

L Soroceanu, E Singer, P Dighe… - Neuro-Oncology …, 2022 - academic.oup.com
Background Cannabidiol (CBD), a nonpsychoactive cannabinoid with a low toxicity profile,
has been shown to produce antitumor activity across cancers in part through selective …

[HTML][HTML] Cannabidiol induces apoptosis and perturbs mitochondrial function in human and canine glioma cells

C Gross, DA Ramirez, S McGrath… - Frontiers in …, 2021 - frontiersin.org
Cannabidiol (CBD), the major non-psychoactive compound found in cannabis, is frequently
used both as a nutraceutical and therapeutic. Despite anecdotal evidence as an anticancer …

[HTML][HTML] Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect

M Solinas, P Massi, V Cinquina, M Valenti… - PLoS …, 2013 - journals.plos.org
In the present study, we found that CBD inhibited U87-MG and T98G cell proliferation and
invasiveness in vitro and caused a decrease in the expression of a set of proteins …

[HTML][HTML] The Combination of Δ9-Tetrahydrocannabinol and Cannabidiol Suppresses Mitochondrial Respiration of Human Glioblastoma Cells via Downregulation of …

A Rupprecht, U Theisen, F Wendt, M Frank, B Hinz - Cancers, 2022 - mdpi.com
Simple Summary Cannabidiol (CBD) is a phytocannabinoid from Cannabis sativa L. that
exhibits no psychoactivity and, like the psychoactive cannabinoid Δ9-tetrahydrocannabinol …

Inhibiting heat shock proteins can potentiate the cytotoxic effect of cannabidiol in human glioma cells

KA Scott, JL Dennis, AG Dalgleish, WM Liu - Anticancer research, 2015 - ar.iiarjournals.org
Cannabinoids possess a number of characteristics that make them putative anticancer
drugs, and their value as such is currently being explored in a number of clinical studies. To …