Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's …

NA Kaidery, R Banerjee, L Yang… - Antioxidants & redox …, 2013 - liebertpub.com
Although the etiology of Parkinson's disease (PD) remains unclear, ample empirical
evidence suggests that oxidative stress is a major player in the development of PD and in 1 …

Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism

A Jazwa, AI Rojo, NG Innamorato, M Hesse… - Antioxidants & redox …, 2011 - liebertpub.com
Current therapies for motor symptoms of Parkinson's disease (PD) are based on dopamine
replacement. However, the disease progression remains unaffected, because of continuous …

Nrf2-mediated protection against 6-hydroxydopamine

RJ Jakel, JA Townsend, AD Kraft, JA Johnson - Brain research, 2007 - Elsevier
Parkinson's disease (PD) is a neurodegenerative movement disorder characterized by cell
loss in the substantia nigra resulting in striatal dopamine depletion. Although the cause of …

In vivo modulation of the Parkinsonian phenotype by Nrf2

NC Burton, TW Kensler, TR Guilarte - Neurotoxicology, 2006 - Elsevier
Oxidative stress has been implicated in the etiology of Parkinson's disease (PD) and in the 1-
methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) animal model of PD. In this report we …

Protective effects of Nrf2–ARE activator on dopaminergic neuronal loss in Parkinson disease model mice: Possible involvement of heme oxygenase-1

Y Inose, Y Izumi, Y Takada-Takatori, A Akaike… - Neuroscience …, 2020 - Elsevier
Parkinson disease (PD) is a neurodegenerative disorder characterized by a selective loss of
dopaminergic neurons in the substantia nigra, and oxidative stress is thought to contribute to …

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

PC Chen, MR Vargas, AK Pani… - Proceedings of the …, 2009 - National Acad Sciences
Oxidative stress has been implicated in the etiology of Parkinson's disease (PD) and in the 1-
methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) animal model of PD. It is known that …

[HTML][HTML] Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription

L Yang, NY Calingasan, B Thomas, RK Chaturvedi… - PloS one, 2009 - journals.plos.org
The NF-E2-related factor-2 (Nrf2)/antioxidant response element (ARE) signaling pathway
regulates phase 2 detoxification genes, including a variety of antioxidative enzymes. We …

[HTML][HTML] Hydralazine Protects Nigrostriatal Dopaminergic Neurons From MPP+ and MPTP Induced Neurotoxicity: Roles of Nrf2-ARE Signaling Pathway

X Guo, C Han, K Ma, Y Xia, F Wan, S Yin, L Kou… - Frontiers in …, 2019 - frontiersin.org
Although the pathogenic mechanisms of Parkinson's disease (PD) remain unclear, ample
empirical evidence suggests that oxidative stress is involved in the pathogenesis of this …

Nrf2 activators provide neuroprotection against 6‐hydroxydopamine toxicity in rat organotypic nigrostriatal cocultures

A Siebert, V Desai, K Chandrasekaran… - Journal of …, 2009 - Wiley Online Library
Oxidative stress and inflammation appear to play a critical role in the progression of
Parkinson's disease. As a result, there has been growing interest in antioxidant pathways …

[HTML][HTML] Pharmacological modulation of Nrf2/HO-1 signaling pathway as a therapeutic target of Parkinson's disease

Y Wang, L Gao, J Chen, Q Li, L Huo, Y Wang… - Frontiers in …, 2021 - frontiersin.org
Parkinson's disease (PD) is a complex neurodegenerative disorder featuring both motor and
nonmotor symptoms associated with a progressive loss of dopaminergic neurons in the …