1. The blood pressure, heart rate, hormonal and pressor responses to constant rate infusion
of various doses of the angiotensin (type 1) receptor antagonist Losartan (DuP 753/MK 954) …

In a dose-ranging study, the angiotensin type I receptor antagonist losartan
(DuP753/MK954) was administered orally to normal volunteers in whom the renin …

Losartan, an angiotensin II type 1 receptor (AT1) antagonist, was developed as a more
specific alternative to angiotensin-converting enzyme (ACE) inhibitors. At a daily dose of 50 …

This study was designed to evaluate in healthy volunteers the renal hemodynamic and
tubular effects of the orally active angiotensin II receptor antagonist losartan (DuP 753 or MK …

Experiments were carried out in conscious dexamethasone-treated cynomolgus monkeys in
an attempt to determine if losartan (DuP753) inhibited endogenous as well as exogenous …

Losartan is an orally active, nonpeptide angiotensin II (Ang II)(site-1) receptor antagonist.
We conducted a multiple-dose study in healthy male volunteers to investigate the tolerability …

To dissociate the renal effects from the systemic effects of angiotensin II blockade, the
present study was designed to determine the effects of systemic and renal interstitial infusion …

The effects of in vivo treatment with the nonpeptide subtype 1 angiotensin II receptor
antagonist, losartan, on blood pressure and vascular reactivity in normotensi male Sprague …

The 1-sarcosine-8-alanine analogue of angiotensin II (1-Sar-8-Ala-angiotensin II) was
infused at 1 and 5 µg/kg min-1 into conscious rabbits on normal or sodium-deficient diets …

We examined the renal hemodynamic modifications induced by a selective angiotensin II
(AII) AT1 receptor antagonist, losartan, in 10 patients with essential hypertension. In this …