Effects of the angiotensin II receptor antagonist losartan (DuP 753/MK 954) on arterial blood pressure, heart rate, plasma concentrations of angiotensin II and renin …
RJ MacFadyen, M Tree, AF Lever, JL Reid - Clinical Science, 1992 - portlandpress.com
1. The blood pressure, heart rate, hormonal and pressor responses to constant rate infusion
of various doses of the angiotensin (type 1) receptor antagonist Losartan (DuP 753/MK 954) …
of various doses of the angiotensin (type 1) receptor antagonist Losartan (DuP 753/MK 954) …
Dose-ranging study of the angiotensin type I receptor antagonist losartan (DuP753/MK954), in salt-deplete normal man
JK Doig, RJ MacFadyen, CS Sweet… - Journal of …, 1993 - journals.lww.com
In a dose-ranging study, the angiotensin type I receptor antagonist losartan
(DuP753/MK954) was administered orally to normal volunteers in whom the renin …
(DuP753/MK954) was administered orally to normal volunteers in whom the renin …
Dose-dependent blockade of the angiotensin II type 1 receptor with losartan in normal volunteers
MS Berlowitz, F Latif, SR Hankins… - Journal of …, 2001 - journals.lww.com
Losartan, an angiotensin II type 1 receptor (AT1) antagonist, was developed as a more
specific alternative to angiotensin-converting enzyme (ACE) inhibitors. At a daily dose of 50 …
specific alternative to angiotensin-converting enzyme (ACE) inhibitors. At a daily dose of 50 …
Salt-dependent renal effects of an angiotensin II antagonist in healthy subjects.
M Burnier, B Rutschmann, J Nussberger, J Versaggi… - …, 1993 - Am Heart Assoc
This study was designed to evaluate in healthy volunteers the renal hemodynamic and
tubular effects of the orally active angiotensin II receptor antagonist losartan (DuP 753 or MK …
tubular effects of the orally active angiotensin II receptor antagonist losartan (DuP 753 or MK …
Hormonal and cardiovascular effects of losartan (DuP753), an angiotensin receptor antagonist, in nonhuman primates.
GL DeGraaf, DT Pals, SJ Couch, JA Lawson - Journal of Pharmacology and …, 1993 - ASPET
Experiments were carried out in conscious dexamethasone-treated cynomolgus monkeys in
an attempt to determine if losartan (DuP753) inhibited endogenous as well as exogenous …
an attempt to determine if losartan (DuP753) inhibited endogenous as well as exogenous …
Effects of losartan on blood pressure, plasma renin activity, and angiotensin II in volunteers.
MR Goldberg, W Tanaka, A Barchowsky… - …, 1993 - Am Heart Assoc
Losartan is an orally active, nonpeptide angiotensin II (Ang II)(site-1) receptor antagonist.
We conducted a multiple-dose study in healthy male volunteers to investigate the tolerability …
We conducted a multiple-dose study in healthy male volunteers to investigate the tolerability …
Comparison of systemic and direct intrarenal angiotensin II blockade on sodium excretion in rats
Y Peng, FG Knox - American Journal of Physiology-Renal …, 1995 - journals.physiology.org
To dissociate the renal effects from the systemic effects of angiotensin II blockade, the
present study was designed to determine the effects of systemic and renal interstitial infusion …
present study was designed to determine the effects of systemic and renal interstitial infusion …
Acute and chronic effects of losartan (DuP 753) on blood pressure and vascular reactivity in normotensive rats
EE Soltis, AL Jewell, LP Dwoskin… - Clinical and Experimental …, 1993 - Taylor & Francis
The effects of in vivo treatment with the nonpeptide subtype 1 angiotensin II receptor
antagonist, losartan, on blood pressure and vascular reactivity in normotensi male Sprague …
antagonist, losartan, on blood pressure and vascular reactivity in normotensi male Sprague …
Differential effects of an angiotensin II analogue on pressor and adrenal receptors in the rabbit
JM Steele Jr, J Lowenstein - Circulation Research, 1974 - Am Heart Assoc
The 1-sarcosine-8-alanine analogue of angiotensin II (1-Sar-8-Ala-angiotensin II) was
infused at 1 and 5 µg/kg min-1 into conscious rabbits on normal or sodium-deficient diets …
infused at 1 and 5 µg/kg min-1 into conscious rabbits on normal or sodium-deficient diets …
Effects of losartan on renal function in patients with essential hypertension
JP Fauvel, S Velon, N Berra, N Pozet… - Journal of …, 1996 - journals.lww.com
We examined the renal hemodynamic modifications induced by a selective angiotensin II
(AII) AT1 receptor antagonist, losartan, in 10 patients with essential hypertension. In this …
(AII) AT1 receptor antagonist, losartan, in 10 patients with essential hypertension. In this …
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