Sažetak Polymyxin antibiotics are the last resort for treating patients in intensive care units
infected with multiple-resistant Gram-negative bacteria. Due to their polycationic structure …

Polymyxins are last-line antibiotics employed against multidrug-resistant (MDR) Klebsiella
pneumoniae. Worryingly, polymyxin resistance is rapidly on the rise globally. Polymyxins …

Polymyxin antibiotics are increasingly being used as last-line therapeutic options against a
number of multidrug resistant bacteria. These antibiotics show strong bactericidal activity …

Multidrug resistance in Pseudomonas aeruginosa is increasingly becoming a threat for
human health. Indeed, some strains are resistant to almost all currently available antibiotics …

Infections caused by multi-drug resistant (MDR) bacterial pathogens are a leading cause of
mortality and morbidity across the world. Indiscriminate use of broad-spectrum antibiotics …

The Role of Lipid A Head Group Modification in Escherichia coli Virulence and Polymyxin
Resistance Page 1 The Role of Lipid A Head Group Modification in Escherichia coli …

The impact of under-acylation of lipid A on the interaction between Klebsiella pneumoniae
LPS and polymyxins B and E was examined with fluorometric and calorimetric methods, and …

Three sets of novel 4-deoxy-l-arabinose analogs were synthesized and evaluated as
potential inhibitors of the bacterial resistance mechanism in which lipid A, on the outer …

Polymyxins are last-line antibiotics against life-threatening multidrug-resistant Gram-
negative bacteria. Unfortunately, polymyxin resistance is increasingly reported, leaving a …

Polymyxins were discovered in the 1940s and were used to treat infections caused by gram-
negative bacteria. These molecules act by destroying the cell membrane through the …