A cross‐study analysis evaluating the effects of food on the pharmacokinetics of rivaroxaban in clinical studies

L Zhang, G Peters, L Haskell, P Patel… - The Journal of …, 2017 - Wiley Online Library
US prescribing guidelines recommend that 15‐and 20‐mg doses of rivaroxaban be
administered with food for the treatment of deep vein thrombosis (DVT) and pulmonary …

A Simple and Efficient Method to Determine Rivaroxaban in Rat Plasma Using Liquid-Liquid Extraction and LC-MRM

HC Lee, DY Kim, MJ Choi, SK Jin, YS Choi - Mass Spectrometry Letters, 2019 - accesson.kr
Rivaroxaban (RRN) is the first available active direct factor Xa inhibitor (anticoagulant) with
oral administration. Due to its success in market, there have been efforts to develop various …

Development of a solid supersaturable micelle of revaprazan for improved dissolution and oral bioavailability using box-behnken design

YT Goo, CK Sa, JY Choi, MS Kim, CH Kim… - International journal …, 2021 - Taylor & Francis
Purpose To enhance the oral bioavailability of revaprazan (RVP), a novel solid,
supersaturable micelle (SSuM) was developed. Methods Surfactants and solid carriers were …

Development and validation of a liquid chromatography method for the analysis of rivaroxaban and determination of its production related impurities

B Arous, MA Al-Mardini, F Karabet… - Pharmaceutical …, 2018 - Springer
The purpose of this work was to develop a sensitive and validated HPLC method for
analysis of rivaroxaban and estimation of related impurities in parent drug substance and …

[PDF][PDF] Stability-indicating UPLC method for determining related substances and degradants in Rivaroxaban.

PSP Rao, VK Cholleti, VR Reddy - International Journal of …, 2015 - ijrpsonline.com
ABSTRACT A simple, sensitive and reproducible method was developed on ultra
performance liquid chromatography (UPLC) coupled with a photodiode array detector for the …

Rivaroxaban concentrations in acute stroke patients with different dosage forms

S Wada, M Inoue, T Matsuki, T Okata, M Kumamoto… - Plos one, 2019 - journals.plos.org
Background The crushed-tablet rivaroxaban concentration has been previously reported to
be lower than the non-crushed concentration. However, the rivaroxaban concentration of …

[PDF][PDF] Rivaroxaban: Compatibilty with pharmaceutical excipients using DSC and FTIR Spectrophotometry

RR Nadendla, J Satynarayana… - Journal of Pharmaceutical …, 2022 - academia.edu
Rivaroxaban (RN) is a recently developed potent oral anticoagulant. The aim of the present
study envisages compatibility studies of rivaroxaban with crospovidone, sodium startch …

A solid self-nanoemulsifying system of the BCS class IIb drug dabigatran etexilate to improve oral bioavailability

F Chai, L Sun, Y Ding, X Liu, Y Zhang, TJ Webster… - …, 2016 - Taylor & Francis
Aim: To develop dabigatran etexilate (DE)-loaded self-nanoemulsifying drug delivery
systems (SNEDDS) for the prevention of stroke and thromboembolism. Materials & methods …

RP-HPLC method development and validation for estimation of rivaroxaban in pharmaceutical dosage forms

M Çelebier, T Reçber, E Koçak… - Brazilian Journal of …, 2013 - SciELO Brasil
Rivaroxaban, an anti-clotting medication, acts at a crucial point in the blood-clotting process
and stops the formation of blood clots. In this study, RP-HPLC method was developed for the …

Oral delivery of posaconazole-loaded phospholipid-based nanoformulation: Preparation and optimization using design of experiments, machine learning, and …

F Bayat, S Dadashzadeh, R Aboofazeli… - International Journal of …, 2024 - Elsevier
Phospholipid-based nanosystems show promising potentials for oral administration of
hydrophobic drugs. The study introduced a novel approach to optimize posaconazole …