Molecular docking, chemo-informatic properties, alpha-amylase, and lipase inhibition studies of benzodioxol derivatives
Currently, available therapies for diabetes could not achieve normal sugar values in a high
percentage of treated patients. In this research project, a series of 17 benzodioxole …
percentage of treated patients. In this research project, a series of 17 benzodioxole …
In silico design of new α-glucosidase inhibitors through 3D-QSAR study, molecular docking modeling and ADMET analysis
A Khaldan, S Bouamrane, REMA Ajana… - Moroccan Journal of …, 2022 - revues.imist.ma
Abstract α-Glucosidase enzyme is a therapeutic target for diabetes mellitus and its inhibitors
shown a crucial importance in the treatment of this disease. Twenty oxindole based …
shown a crucial importance in the treatment of this disease. Twenty oxindole based …
2, 4-Dichloro-5-[(N-aryl/alkyl) sulfamoyl] benzoic acid derivatives: in vitro antidiabetic activity, molecular modeling and in silico ADMET screening
Background: Postprandial hyperglycemia can be reduced by inhibiting major carbohydrate
hydrolyzing enzymes, such as α-glucosidase and α-amylase which is an effective approach …
hydrolyzing enzymes, such as α-glucosidase and α-amylase which is an effective approach …
[HTML][HTML] Aryl-oxadiazole Schiff bases: Synthesis, α-glucosidase in vitro inhibitory activity and their in silico studies
Abstract α-Glucosidase enzyme is a therapeutic target for diabetes mellitus and its inhibitors
play a vital role in the treatment of this disease. A new series of aryl-oxadiazole Schiff bases …
play a vital role in the treatment of this disease. A new series of aryl-oxadiazole Schiff bases …
Biological, toxicological and molecular docking evaluations of isoxazoline-thiazolidine-2, 4-dione analogues as new class of anti-hyperglycemic agents
In this work, three isoxazoline-thiazolidine-2, 4-dione derivatives were synthesized and
characterized by FT-IR, 1H-NMR, 13C-NMR and ESI-MS spectrometry. All compounds have …
characterized by FT-IR, 1H-NMR, 13C-NMR and ESI-MS spectrometry. All compounds have …
Synthesis, biological evaluation and molecular docking study of benzimidazole derivatives as α-glucosidase inhibitors and anti-diabetes candidates
Voglibose and acarbose are distinguished α-glucosidase inhibitors used for controlling
diabetes mellitus. Unfortunately, these distinguished and clinically used inhibitors have also …
diabetes mellitus. Unfortunately, these distinguished and clinically used inhibitors have also …
Synthesis of triazinoindole bearing sulfonamide derivatives, in vitro α-amylase activity and their molecular docking study
Diabetes mellitus is one of the most chronic metabolic diseases. Since past few years, our
research group had synthesized and evaluated libraries of heterocyclic analogues against α …
research group had synthesized and evaluated libraries of heterocyclic analogues against α …
Synthesis, molecular docking study of thiazole derivatives and exploring their dual inhibitor potentials against α-amylase and α-glucosidase
Diabetes mellitus is one of the most chronic metabolic diseases. The current study
comprises of evaluation of thiazole as an antidiabetic agent. A library of sixteen derivatives …
comprises of evaluation of thiazole as an antidiabetic agent. A library of sixteen derivatives …
Synthesis of indole derivatives as diabetics II inhibitors and enzymatic kinetics study of α-glucosidase and α-amylase along with their in-silico study
In this study, we have investigated a series of indole-based compounds for their inhibitory
study against pancreatic α-amylase and intestinal α-glucosidase activity. Inhibitors of …
study against pancreatic α-amylase and intestinal α-glucosidase activity. Inhibitors of …
Identification of potential N-substituted 5-benzylidenethiazolidine-2, 4‑dione derivatives as α-amylase inhibitors: Computational cum synthetic studies
Diabetes mellitus is a chronic metabolic disorder become a major health problem globally
associated with social and economic consequences. α-amylase is an endo-amylase …
associated with social and economic consequences. α-amylase is an endo-amylase …
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