A novel class of nonionic amphipols (NAPols) designed to handle membrane proteins in
aqueous solutions has been synthesized, and its solution properties have been examined …

Integral membrane proteins (IMPs) are crucial cellular components, mediating the transfer of
material and signals between the environment and the cytoplasm, or between different …

Amphipols (APols) are amphipathic polymers with the ability to substitute detergents to keep
membrane proteins (MPs) soluble and functional in aqueous solutions. APols also protect …

Handling integral membrane proteins in aqueous solutions traditionally relies on the use of
detergents, which are surfactants capable of dispersing the components of biological …

Integral membrane proteins have historically been challenging targets for biophysical
research due to their low solubility in aqueous solution. Their importance for chemical and …

Nonionic amphipols (NAPols) synthesized by homotelomerization of an amphiphatic
monomer are able to keep membrane proteins (MPs) stable and functional in the absence of …

As traditional detergents might destabilize or even denature membrane proteins,
amphiphilic polymers have moved into the focus of membrane-protein research in recent …

Screening assays performed against membrane protein targets (eg phage display) are
hampered by issues arising from protein expression and purification, protein stability in …

Cell-free expression of membrane proteins is a way to circumvent some of the problems
encountered during their in vivo expression, among which is the small volume of membrane …

We have developed two functionalized β-sheet peptides (FBPs) and demonstrated that they
can stabilize a variety of integral membrane proteins (IMPs), and most importantly allow …