Objective: To elucidate whether leptin is involved in the etiology of female colorectal cancer.
Methods: A case-control study nested in the Japan Collaborative Cohort Study. We …

Obesity is associated with an increased risk of colorectal cancer. Circulating levels of leptin
are high in obesity and strongly correlated to levels of insulin. Leptin stimulates growth of …

Obesity has been shown to be associated with an increased risk of both colorectal cancer
and adenomatous polyps. One mechanism underlying this relationship may involve the …

Purpose Equivocal results regarding the role of leptin in colorectal cancer (CRC) and
adenoma (CRA) have been reported. A case–control study investigating the association of …

Background & Aims: Obesity increases the risk of colon cancer, whereas physical activity
reduces the risk. Plasma levels of leptin increase in proportion to the level of obesity and are …

Leptin, a peptide hormone produced primarily by the adipocytes, is hypothesized to play a
role in the pathogenesis of colorectal cancer (CRC). Soluble leptin receptor (sOB-R) may …

Background High levels of serum leptin and low levels of serum adiponectin are strongly
correlated with obesity, a well-established risk factor for colorectal cancer (CRC). Growing …

Although a number of recent studies have reported the involvement of leptin in colorectal
carcinogenesis, findings are contradictory and difficult to interpret. Our group has previously …

Obesity, a risk factor for colorectal cancer, is associated with elevated serum levels of leptin,
the adipocyte‐derived hormone, and insulin. Experimental and epidemiologic studies have …

Background: The leptin receptor is involved in modulating leptin activity, acting as a carrier
protein. A link between leptin or leptin receptor and cancer development has been proposed …