Abstract Background The polymorphism Arg16 in β2‐adrenergic receptor (ADRB2) gene
has been associated with an increased risk of exacerbations in asthmatic children treated …

Background: Current evidence suggests that asthma patients with the ADRB2 Arg16
genotype have a poorer response to long-acting β2-agonists (LABA), but the results remain …

Background The Gly-to-Arg substitution at the 16 position (rs1042713) in the β 2-
adrenoceptor gene (ADRB2) is associated with enhanced downregulation and uncoupling …

Background Long‐acting beta2‐agonists (LABA) are recommended in asthma therapy;
however, not all asthma patients respond well to LABA. We performed a systematic review …

Asthma is the leading chronic disease in children. Several studies have identified genetic
biomarkers associated with susceptibility and severity in both adult and pediatric cases. In …

Background. About 9% of children have asthma, corresponding to almost 6.8 million
children in the USA and 1.1 million in the UK. Asthma exacerbations are the leading cause …

BACKGROUND: On-demand inhaled albuterol is commonly prescribed worldwide. We have
shown that the Arg16 allele of the adrenergic β2-receptor agonist gene (ADRB2) …

Background β2 adrenergic receptor (ADRβ2) polymorphisms including ADRβ2+ 46G> A
have been reported to cause adverse outcomes in mild asthmatics. The extent to which …

METHODS: We analyzed data from a large 6-month double-blind trial (SD-039-0735) from
2250 patients who consented to provide DNA for genetic studies. Patients≥ 12 years old …

Background and Objective A number of studies have assessed the relationship between
beta-2 adrenergic receptor (ADRB2) gene polymorphisms and asthma risk. However, the …