Bicyclol attenuates obesity-induced cardiomyopathy via inhibiting NF-κB and MAPK signaling pathways

Y Chen, W Lin, L Zhong, Z Fang, B Ye, Z Wang… - … Drugs and Therapy, 2023 - Springer
Purpose Schisandra is a well-known traditional Chinese medicine in East Asia. As a
traditional Chinese medicine derivative with Schisandra chinensis as raw material, bicyclol …

Bicyclol alleviates streptozotocin-induced diabetic cardiomyopathy by inhibiting chronic inflammation and oxidative stress

L Zhang, C Hu, B Jin, B Bai, J Liao, L Jin… - … Drugs and Therapy, 2024 - Springer
Purpose Diabetic cardiomyopathy (DCM) is a common and severe complication of diabetes.
Inflammation and oxidative stress play important roles in DCM development. Bicyclol is a …

[HTML][HTML] Curcumin analogue C66 attenuates obesity-induced myocardial injury by inhibiting JNK-mediated inflammation

L Ye, X Chen, M Wang, L Jin, Z Zhuang, D Yang… - Biomedicine & …, 2021 - Elsevier
Obesity has been recognized as a major risk factor for the development of chronic
cardiomyopathy, which is associated with increased cardiac inflammation, fibrosis, and …

Berberine improves dietary-induced cardiac remodeling by upregulating Kruppel-like factor 4-dependent mitochondrial function

L Ding, S Li, F Wang, J Xu, S Li, B Wang, J Kou… - Biological …, 2021 - degruyter.com
Multiple studies have showed that berberine protects against heart diseases, including
obesity-associated cardiomyopathy. However, it is not fully disclosed the potential molecular …

[HTML][HTML] Bawei chenxiang wan ameliorates cardiac hypertrophy by activating AMPK/PPAR-α signaling pathway improving energy metabolism

X Zhang, Z Zhang, P Wang, Y Han, L Liu, J Li… - Frontiers in …, 2021 - frontiersin.org
Bawei Chenxiang Wan (BCW), a well-known traditional Chinese Tibetan medicine formula,
is effective for the treatment of acute and chronic cardiovascular diseases. In the present …

Tabersonine alleviates obesity‐induced cardiomyopathy by binding to Transforming growth factor activated kinase 1 (TAK1) and inhibiting TAK1‐mediated …

Y Chen, W Lin, P Chen, B Ye, W Luo… - Phytotherapy …, 2023 - Wiley Online Library
Obesity‐induced cardiomyopathy (OIC) is an increasingly serious global disease caused by
obesity. Chronic inflammation greatly contributes to the pathogenesis of OIC. This study …

Short‐Term Lenalidomide (Revlimid) Administration Ameliorates Cardiomyocyte Contractile Dysfunction in ob/ob Obese Mice

L Li, Y Hua, M Dong, Q Li, DT Smith, M Yuan… - …, 2012 - Wiley Online Library
Lenalidomide is a potent immunomodulatory agent capable of downregulating
proinflammatory cytokines such as tumor necrosis factor‐α (TNF‐α) and upregulating anti …

Shikonin ameliorates isoproterenol (ISO)-induced myocardial damage through suppressing fibrosis, inflammation, apoptosis and ER stress

J Yang, Z Wang, DL Chen - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Shikonin, isolated from the roots of herbal plant Lithospermum erythrorhizon, is a
naphthoquinone. It has been reported to exert beneficial anti-inflammatory effects and anti …

[HTML][HTML] Breviscapine ameliorates hypertrophy of cardiomyocytes induced by high glucose in diabetic rats via the PKC signaling pathway

M Wang, W Zhang, J Zhu, G Fu, B Zhou - Acta Pharmacologica Sinica, 2009 - nature.com
Aim: To investigate the influence of breviscapine on high glucose-induced hypertrophy of
cardiomyocytes and the relevant mechanism in vitro and in vivo. Methods: Cultured neonatal …

β-elemene alleviates hyperglycemia-induced cardiac inflammation and remodeling by inhibiting the JAK/STAT3-NF-κB pathway

J Wang, C Qian, Y Chen, T Jin, Y Jiang, L Huang, X Fu… - Phytomedicine, 2023 - Elsevier
Background Hyperglycemic induced cardiac hypertrophy and cardiac inflammation are
important pathological processes in diabetic cardiomyopathy. β-elemene (Ele) is a natural …