Elevated sCD163 in plasma but not cerebrospinal fluid is a marker of neurocognitive impairment in HIV infection
Objective: Here we evaluated whether neurocognitive disorders in HIV-infected individuals
on effective antiretroviral therapy (ART) are associated with persistent monocyte activation …
on effective antiretroviral therapy (ART) are associated with persistent monocyte activation …
Soluble CD163 made by monocyte/macrophages is a novel marker of HIV activity in early and chronic infection prior to and after anti-retroviral therapy
TH Burdo, MR Lentz, P Autissier… - Journal of Infectious …, 2011 - academic.oup.com
CD163, a monocyte-and macrophage-specific scavenger receptor, is shed during activation
as soluble CD163 (sCD163). We have previously demonstrated that monocyte expansion …
as soluble CD163 (sCD163). We have previously demonstrated that monocyte expansion …
Plasma soluble CD163 level independently predicts all-cause mortality in HIV-1–infected individuals
TB Knudsen, G Ertner, J Petersen… - The Journal of …, 2016 - academic.oup.com
Abstract Background. CD163, a monocyte-and macrophage-specific scavenger receptor, is
shed as soluble CD163 (sCD163) during the proinflammatory response. Here, we assessed …
shed as soluble CD163 (sCD163) during the proinflammatory response. Here, we assessed …
[HTML][HTML] Differential expression of CD163 on monocyte subsets in healthy and HIV-1 infected individuals
E Tippett, WJ Cheng, C Westhorpe, PU Cameron… - PloS one, 2011 - journals.plos.org
CD163, a haptoglobin-hemoglobin (Hp-Hb) scavenger receptor, expressed by monocytes
and macrophages, is important in resolution of inflammation. Age-related non-AIDS co …
and macrophages, is important in resolution of inflammation. Age-related non-AIDS co …
[HTML][HTML] Monocyte activation is associated with worse cognitive performance in HIV-infected women with virologic suppression
BM Imp, LH Rubin, PC Tien, MW Plankey… - The Journal of …, 2017 - ncbi.nlm.nih.gov
Background. Cognitive impairment persists despite suppression of plasma human
immunodeficiency virus (HIV) RNA. Monocyte-related immune activation is a likely …
immunodeficiency virus (HIV) RNA. Monocyte-related immune activation is a likely …
Plasma and cerebrospinal fluid biomarkers predict cerebral injury in HIV-infected individuals on stable combination antiretroviral therapy
AM Anderson, J Harezlak, A Bharti, D Mi… - JAIDS Journal of …, 2015 - journals.lww.com
Objectives: HIV-associated brain injury persists despite combination antiretroviral therapy,
but contributing factors remain poorly understood. We postulated that inflammation …
but contributing factors remain poorly understood. We postulated that inflammation …
[HTML][HTML] Central and peripheral markers of neurodegeneration and monocyte activation in HIV-associated neurocognitive disorders
HIV-associated neurocognitive disorders (HAND) affect up to 50% of HIV-infected adults,
independently predict HIV morbidity/mortality, and are associated with neuronal damage …
independently predict HIV morbidity/mortality, and are associated with neuronal damage …
CD163, a marker of perivascular macrophages, is up-regulated by microglia in simian immunodeficiency virus encephalitis after haptoglobin-hemoglobin complex …
Macrophages and microglia are the major cell types infected by human immunodeficiency
virus and simian immunodeficiency virus (SIV) in the central nervous system. Microglia are …
virus and simian immunodeficiency virus (SIV) in the central nervous system. Microglia are …
Monocyte activation markers in cerebrospinal fluid associated with impaired neurocognitive testing in advanced HIV infection
Background: Activated monocytes/macrophages play a role in severe forms of HIV-
associated neurocognitive disorders (HAND), but little is known about the mechanisms …
associated neurocognitive disorders (HAND), but little is known about the mechanisms …
Evidence of CNS impairment in HIV infection: clinical, neuropsychological, EEG, and MRI/MRS study
MJG Harrison, SP Newman, MA Hall-Craggs… - Journal of Neurology …, 1998 - jnnp.bmj.com
OBJECTIVES To identify by clinical examination, EEG, MRI, and proton spectroscopy, and
neuropsychological assessment the prevalence of signs of CNS involvement in patients …
neuropsychological assessment the prevalence of signs of CNS involvement in patients …
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