Leptin regulation of cancer stem cells in breast and gynecologic cancer

KK Crean-Tate, O Reizes - Endocrinology, 2018 - academic.oup.com
It is well established that obesity increases the incidence and worsens the prognosis of
women's cancer. For breast cancer, women with obesity exhibit more than a twofold …

Obesity-Induced Leptin-Signaling Pathways to Gynecologic Cancers

T Tabassum, S Khan - Obesity: Clinical, Surgical and Practical Guide, 2024 - Springer
Obesity is related to many major diseases and cancers. Obesity-linked leptin has been
studied extensively in many cancer types. Leptin has been positively correlated with cancer …

Linking obesity-induced leptin-signaling pathways to common endocrine-related cancers in women

E Nyasani, I Munir, M Perez, K Payne, S Khan - Endocrine, 2019 - Springer
Obesity is related to many major diseases and cancers. Women have higher rates of obesity
and obesity is linked to commonly occurring cancers in women. However, there is a lack of …

Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells

S Guo, M Liu, G Wang, M Torroella-Kouri… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Significant correlations between obesity and incidence of various cancers have been
reported. Obesity, considered a mild inflammatory process, is characterized by a high level …

The multifactorial role of leptin in driving the breast cancer microenvironment

S Ando, S Catalano - Nature reviews endocrinology, 2012 - nature.com
Adipose-tissue-derived signaling molecules, including the adipokines, are emerging as key
candidate molecules that link obesity with cancer. Peritumoral, stromal, adipose tissue and …

[PDF][PDF] Leptin-regulated gene expression in MCF-7 breast cancer cells: mechanistic insights into leptin-regulated mammary tumor growth and progression

CN Perera, HG Chin, N Duru, IG Camarillo - Journal of Endocrinology, 2008 - Citeseer
Obesity is a recently established risk factor for breast cancer incidence and mortality. A
characteristic of obesity is elevated circulating levels of adipocyte-derived hormone leptin …

Obesity and breast cancer: role of leptin

F Sánchez-Jiménez, A Pérez-Pérez… - Frontiers in …, 2019 - frontiersin.org
Obesity-related breast cancer is an important threat that affects especially post-menopausal
women. The link between obesity and breast cancer seems to be relying on the …

Leptin and cancer: from cancer stem cells to metastasis

J Park, PE Scherer - Endocrine-related cancer, 2011 - erc.bioscientifica.com
There is growing evidence that obesity is a risk factor of cancer incidence and mortality.
Hence, the identification of the mechanistic links between obesity and cancer progression is …

[HTML][HTML] Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: an explanation for poor outcomes in obese women

S Kato, L Abarzua-Catalan, C Trigo, A Delpiano… - Oncotarget, 2015 - ncbi.nlm.nih.gov
The evidence linking obesity with ovarian cancer remains controversial. Leptin is expressed
at higher levels in obese women and stimulates cell migration in other epithelial cancers …

The biology of leptin and its implications in breast cancer: a general view

MJ García-Robles, JE Segura-Ortega… - Journal of interferon & …, 2013 - liebertpub.com
Obesity is a world health problem that increases the risk for developing type 2 diabetes,
cardiovascular disease, fatty liver, and some types of cancer. In postmenopausal women, it …