STRESS PROTEINS AND IMMUNOLOGY Page 1 Annu. Rev. [mmunol. 1990.8:401-20 Copyright
© 1990 by Annual Reviews [nco All rights reserved STRESS PROTEINS AND IMMUNOLOGY …

Stress proteins have been highly conserved during evolution not only because of their
fundamental importance in the response of the cell to stressful assaults, but also because …

The heat shock or stress response is one of the most highly conserved adaptive responses
in nature. In single cell organisms, the stress response confers tolerance to a variety of …

Prokaryotic and eukaryotic cells respond to potentially damaging stimuli such as elevated
temperature by increasing the synthesis of a family of proteins collectively known as stress …

A field of research that began with a curious observation in Drosophila has resulted in a new
understanding of how cells respond to sudden and adverse changes in their environment. In …

Cells have developed a number of different strategies to deal with adverse changes in their
environment. Examples include the temporary amplification of gene expression (eg …

At birth, the immune system is biased toward recognition of microbial antigens in order to
protect the host from infection. Recent data suggest that an important initial line of defense in …

Extracellular cell stress proteins are highly conserved phylogenetically and have been
shown to act as powerful signalling agonists and receptors for selected ligands in several …

Stressors can positively or adversely affect immune and inflammatory responses. However,
the current understanding of these effects at the cellular and molecular levels is not sufficient …

Stress proteins are frequently the target of humoral and cell-mediated immune responses to
infection. These proteins belong to highly conserved gene families and there is substantial …