Diminished anabolic signaling response to insulin induced by intramuscular lipid accumulation is associated with inflammation in aging but not obesity
DA Rivas, DJ McDonald, NP Rice… - American Journal …, 2016 - journals.physiology.org
The loss of skeletal muscle mass is observed in many pathophysiological conditions,
including aging and obesity. The loss of muscle mass and function with aging is defined as …
including aging and obesity. The loss of muscle mass and function with aging is defined as …
Muscle ectopic fat deposition contributes to anabolic resistance in obese sarcopenic old rats through e IF 2α activation
N Tardif, J Salles, C Guillet, J Tordjman, S Reggio… - Aging cell, 2014 - Wiley Online Library
Obesity and aging are characterized by decreased insulin sensitivity (IS) and muscle protein
synthesis. Intramuscular ceramide accumulation has been implicated in insulin resistance …
synthesis. Intramuscular ceramide accumulation has been implicated in insulin resistance …
Short-term muscle disuse atrophy is not associated with increased intramuscular lipid deposition or a decline in the maximal activity of key mitochondrial enzymes in …
BT Wall, ML Dirks, T Snijders, FB Stephens… - Experimental …, 2015 - Elsevier
Aging is generally accompanied by a progressive loss of skeletal muscle mass and
impairments in metabolic function. Even a few days of muscle disuse (such as that occurring …
impairments in metabolic function. Even a few days of muscle disuse (such as that occurring …
Intramuscular lipid metabolism, insulin action, and obesity
LA Consitt, JA Bell, JA Houmard - IUBMB life, 2009 - Wiley Online Library
With the increasing prevalence of obesity, research has focused on the molecular
mechanism (s) linking obesity and skeletal muscle insulin resistance. Metabolic alterations …
mechanism (s) linking obesity and skeletal muscle insulin resistance. Metabolic alterations …
Long‐Chain Fatty Acids and Inflammatory Markers Coaccumulate in the Skeletal Muscle of Sarcopenic Old Rats
T Laurentius, R Kob, C Fellner, M Nourbakhsh… - Disease …, 2019 - Wiley Online Library
Obesity and inflammation are reportedly associated with the pathogenesis of sarcopenia,
which is characterized by age‐related loss of skeletal muscle mass. Intramuscular fat …
which is characterized by age‐related loss of skeletal muscle mass. Intramuscular fat …
Enhanced lipid oxidation and maintenance of muscle insulin sensitivity despite glucose intolerance in a diet-induced obesity mouse model
KE Trajcevski, HM O'Neill, DC Wang, MM Thomas… - PLoS …, 2013 - journals.plos.org
Background Diet-induced obesity is a rising health concern which can lead to the
development of glucose intolerance and muscle insulin resistance and, ultimately, type II …
development of glucose intolerance and muscle insulin resistance and, ultimately, type II …
Influence of exercise training on skeletal muscle insulin resistance in aging: spotlight on muscle ceramides
Intramuscular lipid accumulation has been associated with insulin resistance (IR), aging,
diabetes, dyslipidemia, and obesity. A substantial body of evidence has implicated …
diabetes, dyslipidemia, and obesity. A substantial body of evidence has implicated …
Obesity-associated insulin resistance in skeletal muscle: role of lipid accumulation and physical inactivity
K Eckardt, A Taube, J Eckel - Reviews in Endocrine and Metabolic …, 2011 - Springer
An alarming increase in the prevalence of obesity, type 2 diabetes mellitus, and associated
diseases can be observed world-wide during the past 20 years. In obesity, profound …
diseases can be observed world-wide during the past 20 years. In obesity, profound …
Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid–induced insulin resistance
S Schenk, JF Horowitz - The Journal of clinical investigation, 2007 - Am Soc Clin Investig
Fatty acid oversupply is a key mediator of skeletal muscle insulin resistance in obesity,
primarily via accumulation of fatty acid metabolites and activation of proinflammatory …
primarily via accumulation of fatty acid metabolites and activation of proinflammatory …
Relative contribution of intramyocellular lipid to whole-body fat oxidation is reduced with age but subsarcolemmal lipid accumulation and insulin resistance are only …
C Chee, CE Shannon, A Burns, AL Selby… - Diabetes, 2016 - Am Diabetes Assoc
Insulin resistance is closely related to intramyocellular lipid (IMCL) accumulation, and both
are associated with increasing age. It remains to be determined to what extent perturbations …
are associated with increasing age. It remains to be determined to what extent perturbations …