Nociceptin/Orphanin FQ (N/OFQ) appears to contribute to the development of morphine
tolerance, as blockade of its actions will block or reverse the process. To better understand …

Severe pain occurs in the context of many diseases and conditions and is a leading cause of
disability. Nociceptin/orphanin FQ (N/OFQ) is the endogenous ligand of the N/OFQ peptide …

It has been hypothesized that morphine tolerance and dependence in mice following
chronic exposure may reflect increased compensatory activity of antiopioid systems. The …

Nociceptin/orphanin FQ (N/OFQ) is a neuropeptide that exerts antiopiate effects under some
circumstances, and there is evidence that it contributes to opiate tolerance. This raises the …

Recent evidence from studies in mice lacking the opioid receptor‐like (ORL‐1) receptor and
from experiments using antibodies raised against orphanin FQ/nociceptin (OFQ/N) suggest …

Nociceptin/orphanin FQ (N/OFQ) has been demonstrated to modulate nociceptive
transmission via selective activation of N/OFQ peptide (NOP) receptors. Despite huge …

Nociceptin/orphanin FQ (NC) and its receptor (OP 4) represent a novel peptide/receptor
system which has been implicated in the regulation of various central functions, including …

The development of tolerance to the antinociceptive effect is a main problem associated with
the repeated administration of opioids. The progressively higher doses required to relieve …

Whilst the nociceptin/orphanin FQ (N/OFQ) receptor (NOP) has similar intracellular coupling
mechanisms to opioid receptors, it has distinct modulatory effects on physiological functions …

Nociceptin opioid peptide (NOP) receptor modulates pain transmission and is considered a
prospective target for pain management. Under acute pain conditions in rodents, however …