Inflammatory monocytes and tissue-resident macrophages are key regulators of tissue
repair, regeneration, and fibrosis. After tissue injury, monocytes and macrophages undergo …

Tissue injury triggers a complex series of cellular responses, starting from inflammation
activated by tissue and cell damage and proceeding to healing. By clearing cell debris …

Macrophages regulate tissue regeneration following injury. They can worsen tissue injury by
producing reactive oxygen species and other toxic mediators that disrupt cell metabolism …

Abstract Purpose of Review Macrophages are central players in the immune response
following tissue injury. These cells perform many functions, and the changing tissue …

Macrophages are essential for the efficient healing of numerous tissues, and they contribute
to impaired healing and fibrosis. Tissue repair proceeds through overlapping phases of …

Certain macrophage phenotypes contribute to tissue fibrosis, but why? Tissues host resident
mononuclear phagocytes for their support to maintain homeostasis. Upon injury the …

Macrophages are tissue-resident or infiltrated immune cells critical for innate immunity,
normal tissue development, homeostasis, and repair of damaged tissue. Macrophage …

Inflammation must be tightly regulated to both defend against pathogens and restore tissue
homeostasis. The resolution of inflammatory responses is a dynamic process orchestrated …

Current macrophage phenotype classifications are based on distinct in vitro culture
conditions that do not adequately mirror complex tissue environments. In vivo monocyte …

Tissue regeneration after body injury has always been a complex problem to resolve for
mammals. In adult mammals, the repair process after tissue injury is often accompanied by …