Pharmacokinetic disposition of cepharanthin following single and multiple intravenous doses in healthy subjects

K YASUDA, M MORO, M AKASU… - Rinsho yakuri/Japanese …, 1989 - jstage.jst.go.jp
The pharmacokinetic disposition of Cepharanthin, a biscoclaurine alkaloid, was investigated
in healthy subjects following single intravenous doses of 25, 50, and 100mg and during and …

Pharmacokinetic study of cepharanthin following single oral doses in healthy subjects

K YASUDA, M MORO, A OHNISHI… - … /Japanese Journal of …, 1989 - jstage.jst.go.jp
抄録 The pharmacokinetic disposition of Cepharanthin, a biscoclaurine alkaloid, was
investigatedin healthy subjects following single oral doses of 10, 30, 60, and 120mg. For 30 …

Determination of cepharanthine in rat plasma by LC–MS/MS and its application to a pharmacokinetic study

Y Deng, W Wu, S Ye, W Wang, Z Wang - Pharmaceutical biology, 2017 - Taylor & Francis
Context: Cepharanthine (CPA) has been reported to possess a wide range of
pharmacological activities. Objective: This study investigates the pharmacokinetic …

[HTML][HTML] Pharmacological activity of cepharanthine

K Liu, B Hong, S Wang, F Lou, Y You, R Hu, A Shafqat… - Molecules, 2023 - mdpi.com
Cepharanthine, a natural bisbenzylisoquinoline (BBIQ) alkaloid isolated from the plant
Stephania Cephalantha Hayata, is the only bisbenzylisoquinoline alkaloid approved for …

Cepharanthine: An update of its mode of action, pharmacological properties and medical applications

C Bailly - Phytomedicine, 2019 - Elsevier
Background Cepharanthine (CEP) is a drug used in Japan since the 1950s to treat a
number of acute and chronic diseases, including treatment of leukopenia, snake bites …

Simple, sensitive and rapid HPLC–MS/MS method for the determination of cepharanthine in human plasma

G Hao, H Liang, Y Li, H Li, H Gao, G Liu… - Journal of Chromatography …, 2010 - Elsevier
A rapid, sensitive and specific method for the determination of cepharanthine in human
plasma using high performance liquid chromatography coupled with tandem mass …

Pharmacokinetics of cefamandole using a HPLC assay

NS Aziz, JG Gambertoglio, ET Lin, H Grausz… - … of Pharmacokinetics and …, 1978 - Springer
A pharmacokinetic study was carried out on six normal healthy adults with average
creatinine clearances ranging from 94.8 to 129.3 ml/min. Cefamandole, 15 mg/kg, was …

Observations in man on some pharmacologic features of cefamandole

WE Grose, GP Bodey, D Stewart - Clinical Pharmacology & …, 1976 - Wiley Online Library
Comparative studies of cefamandole and cephalothin were carried out in 32 cancer patients.
After rapid intravenous injection of 1 gm cefamandole or cephalothin, the peak mean serum …

HPLC method of analysis of cephadroxil and its application in bioavailability studies

AG Eshra, EM Hassan… - Journal of Clinical …, 1993 - Wiley Online Library
SUMMARY A rapid, simple, sensitive and accurate HPLC method, for the determination of
cephadroxil in urine, is presented using paracetamol as an internal standard. The urine …

Bioanalysis of cepharanthine by LC–ESI–MS–MS and its application to pharmacokinetic studies

RH Dong, ZZ Fang, HZ Gao, GT Hao, G Liu, TT Shan… - Chromatographia, 2011 - Springer
A sensitive liquid chromatography–electrospray ionization–tandem mass spectrometry (LC–
ESI–MS–MS) method was developed and validated for the quantification of cepharanthine …