Usually, patients participating in clinical trials have a passive role as test persons. This
creates a risk that patients' needs and interests are not reflected in clinical research. The aim …

Background Randomized controlled trial (RCT) trial designs exist on an explanatory-
pragmatic spectrum, depending on the degree to which a study aims to address a question …

Background The translation of evidence from clinical trials into practice is complex. One
approach to facilitating this translation is to consider the 'implementability'of trials as they are …

Importance Patient and family engagement in research may improve the design, conduct,
and dissemination of clinical research, but little is known about whether these stakeholder …

Plain English summary With the growing movement to engage patients in research,
questions are being asked about who is engaging patients and how they are being …

Abstract Background Open Science is 'the movement to make scientific research, data and
dissemination accessible to all levels of an inquiring society'. In the spirit of the Open …

Introduction Patient involvement (PI) in systematic reviews (SRs) can help to improve the
quality of SRs and enhance the credibility of the research process. At the same time, PI in …

Objective Research cannot advance without the voluntary participation of human
participants. Summary of arguments Full participation of research participants is often …

Background Recruitment and retention of participants in randomised controlled trials (RCTs)
is a key determinant of success but is challenging. Trialists and UK Clinical Research …

Background The oversight and conduct of a randomised controlled trial involves several
stakeholders, including a Trial Steering Committee (TSC), Trial Management Group (TMG) …