A systematic, diversity‐oriented synthesis approach was employed to access a natural
product‐inspired flavonoid library with diverse chemical features, including chemical …

Diversity-oriented synthesis has historically focused on the generation of small-molecule
collections with considerable scaffold, stereochemical, and appendage diversity. Recently …

Natural products provide the inspiration for a variety of strategies used in the diversity-
oriented synthesis of novel small-molecule libraries. These libraries can be based on core …

Diversity-oriented synthesis (DOS) has historically focused on the development of small-
molecule collections with considerable chemical diversity with the hypothesis that chemical …

Traditional natural products discovery using a combination of live/dead screening followed
by iterative bioassay-guided fractionation affords no information about compound structure …

Natural products and their derivatives continue to be wellsprings of nascent therapeutic
potential. However, many laboratories have limited resources for biological evaluation …

Designing better small-molecule discovery libraries requires having methods to assess the
consequences of different synthesis decisions on the biological performance of resulting …

Natural product libraries contain specialized metabolites derived from plants, animals, and
microorganisms that play a pivotal role in drug discovery due to their immense structural …

Existing drugs address a relatively narrow range of biological targets. As a result, libraries of
drug-like molecules have proven ineffective against a variety of challenging targets, such as …

The success of natural product-based drug discovery is predicated on having chemical
collections that offer broad coverage of metabolite diversity. We propose a simple set of tools …