Embryonic stem cells can differentiate in vitro into hematopoietic cells through two
intermediate stages; the first being FLK1+ E-cadherin− proximal lateral mesoderm and the …

The growth and differentiation of hematopoietic stem cells are highly dependent on
regulatory molecules produced by stromal cells of the marrow environment. Evidence has …

The mechanisms by which intravenously (IV)-administered hematopoietic cells home to the
bone marrow (BM) are poorly defined. Although insightful information has been obtained in …

Hematopoietic stem cells (HSCs) are self-renewing multipotent stem cells that generate
mature blood lineages throughout life. They, together with hematopoietic progenitor cells …

Mice chimeric for the expression of α4 integrins were used to dissect the roles of these
receptors in development and traffic of lymphoid and myeloid cells. During fetal life, T cell …

We have explored the functional implications of inducible α4 integrin deletion during adult
hematopoiesis by generating a conditional-knockout mouse model, and we show that α4 …

Despite the wide use of mobilized peripheral blood (PB) progenitor cells (PBPC) for clinical
transplantation the mechanism (s) underlying their mobilization and subsequent engraftment …

The platelet glycoprotein IIb (αIIb; CD41) constitutes the alpha subunit of a highly expressed
platelet surface integrin protein. We demonstrate that CD41 serves as the earliest marker of …

In the course of ontogeny, the homing site for the hematopoietic stem cells (HSC) moves
with certain predictability from the yolk sac to the liver/spleen and then to the marrow. The …

We have characterized the emerging hematopoietic system in the human embryo and fetus.
Two embryonic organs, the yolk sac and aorta, support the primary emergence of …