Nucleotides as new co-formers in co-amorphous systems: Enhanced dissolution rate, water solubility and physical stability
X Liu, L Shen, L Zhou, W Wu, G Liang, Y Zhao… - European Journal of …, 2024 - Elsevier
Developing co-amorphous systems is an attractive strategy to improve the dissolution rate of
poorly water-soluble drugs. Various co-formers have been investigated. However, previous …
poorly water-soluble drugs. Various co-formers have been investigated. However, previous …
On the role of salt formation and structural similarity of co-formers in co-amorphous drug delivery systems
Co-amorphous drug delivery systems based on amino acids as co-formers have shown
promising potential to improve the solubility and bioavailability of poorly water-soluble …
promising potential to improve the solubility and bioavailability of poorly water-soluble …
Comparison of co-former performance in co-amorphous formulations: Single amino acids, amino acid physical mixtures, amino acid salts and dipeptides as co-formers
Co-amorphous systems have been shown to be a potential approach to address the poor
water solubility challenge of many drugs. Various low molecular weight molecules …
water solubility challenge of many drugs. Various low molecular weight molecules …
Dipeptides as co-formers in co-amorphous systems
W Wu, K Löbmann, J Schnitzkewitz, A Knuhtsen… - European Journal of …, 2019 - Elsevier
Drug-amino acid co-amorphous systems have become increasingly well-investigated
systems to improve dissolution rate of poorly water-soluble drugs. In this study, dipeptides …
systems to improve dissolution rate of poorly water-soluble drugs. In this study, dipeptides …
Aspartame as a co-former in co-amorphous systems
W Wu, K Löbmann, J Schnitzkewitz, A Knuhtsen… - International journal of …, 2018 - Elsevier
Co-amorphous drug delivery systems are a promising approach to improve the dissolution
rate and therefore potentially the oral bioavailability of poorly-water soluble drugs. Several …
rate and therefore potentially the oral bioavailability of poorly-water soluble drugs. Several …
[HTML][HTML] Dissolution changes in drug-amino acid/biotin co-amorphous systems: decreased/increased dissolution during storage without recrystallization
Z Zou, Q Huang, X Li, X Liu, L Yin, Y Zhao… - European Journal of …, 2023 - Elsevier
Co-amorphous systems have been proven to be a promising strategy to address the poor
water solubility of poorly water-soluble drugs. Generally, the initial dissolution behaviors …
water solubility of poorly water-soluble drugs. Generally, the initial dissolution behaviors …
[HTML][HTML] Improving co-amorphous drug formulations by the addition of the highly water soluble amino acid, proline
Co-amorphous drug amino acid mixtures were previously shown to be a promising
approach to create physically stable amorphous systems with the improved dissolution …
approach to create physically stable amorphous systems with the improved dissolution …
Tannic acid as a co-former in co-amorphous systems: Enhancing their physical stability, solubility and dissolution behavior
H Fael, AL Demirel - International journal of pharmaceutics, 2020 - Elsevier
Co-amorphous systems have been increasingly investigated to improve the solubility and
dissolution rate of poorly soluble drugs. Considering the ability of tannic acid (TA), a …
dissolution rate of poorly soluble drugs. Considering the ability of tannic acid (TA), a …
Amphiphilic disodium glycyrrhizin as a co-former for ketoconazole co-amorphous systems: Biopharmaceutical properties and underlying molecular mechanisms
Y Yang, Y Ke, W Xie, Z Li, L Tao, W Shen… - International Journal of …, 2024 - Elsevier
Co-amorphous systems (CAMs) have been extensively investigated to improve the
dissolution of hydrophobic drugs. However, drug precipitation during the storage or …
dissolution of hydrophobic drugs. However, drug precipitation during the storage or …
Amino acids as co-amorphous stabilizers for poorly water soluble drugs–Part 1: Preparation, stability and dissolution enhancement
K Löbmann, H Grohganz, R Laitinen, C Strachan… - European journal of …, 2013 - Elsevier
Poor aqueous solubility of an active pharmaceutical ingredient (API) is one of the most
pressing problems in pharmaceutical research and development because up to 90% of new …
pressing problems in pharmaceutical research and development because up to 90% of new …