Renal hypertrophy and extracellular matrix accumulation are early features of diabetic
nephropathy. Hyperglycemia-induced oxidative stress is implicated in the etiology of …

Resveratrol (RSV) is reported to have renoprotective activity against diabetic nephropathy,
while the mechanisms underlying its function have not been fully elucidated. In this study …

Diabetic nephropathy (DN) is a metabolic disease characterized by mesangial cell
proliferation and extracellular matrix (ECM) accumulation. Salidroside (SAL) is the major …

Background Diabetic nephropathy (DN) has been recognized as the leading cause of end-
stage renal disease. Resveratrol (RSV), a polyphenolic compound, has been indicated to …

Hyperglycemia-mediated oxidative stress plays a crucial role in the progression of diabetic
nephropathy. Hence, the present study was hypothesized to explore the renoprotective …

Renal interstitial fibrosis is a major pathologic feature of diabetic nephropathy, while the
pathogenesis and therapeutic interventions of diabetic renal interstitial fibrosis are not well …

Diabetic nephropathy is a major complication of diabetes leading to end-stage renal
disease, which requires hemodialysis. Although the mechanism by which it progresses is …

Oxidative stress has been known to play an important role in the development and
progression of diabetic nephropathy, but the intracellular signal transduction pathways …

Glomerular hypertrophy and hyperfiltration are the two major pathological characteristics of
the early stages of diabetic nephropathy (DN), which are respectively related to mesangial …

Background. Epithelial‐to‐mesenchymal transition (EMT) is thought to play a significant role
in the advancement to chronic kidney disease and contributes to the deposition of …