Heterocyclic scaffolds: centrality in anticancer drug development

I Ali, M Nadeem Lone, ZA Al-Othman… - Current drug …, 2015 - ingentaconnect.com
Cancer has been cursed for human beings for long time. Millions people lost their lives due
to cancer. Despite of the several anticancer drugs available, cancer cannot be cured; …

Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets

A Mushtaq, P Wu, MM Naseer - Pharmacology & Therapeutics, 2023 - Elsevier
Cancer, a noncommunicable disease, is the leading cause of mortality worldwide and is
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …

[HTML][HTML] Heterocyclic anticancer compounds: recent advances and the paradigm shift towards the use of nanomedicine's tool box

P Martins, J Jesus, S Santos, LR Raposo… - Molecules, 2015 - mdpi.com
The majority of heterocycle compounds and typically common heterocycle fragments
present in most pharmaceuticals currently marketed, alongside with their intrinsic versatility …

Modern advances in heterocyclic chemistry in drug discovery

AP Taylor, RP Robinson, YM Fobian… - Organic & …, 2016 - pubs.rsc.org
New advances in synthetic methodologies that allow rapid access to a wide variety of
functionalized heterocyclic compounds are of critical importance to the medicinal chemist as …

Recent Advances and Developments of in vitro Evaluation of Heterocyclic Moieties on Cancer Cell Lines

R Tandon, I Singh, V Luxami, N Tandon… - The Chemical …, 2019 - Wiley Online Library
Besides worthy development in cancer therapy, cancer is still one of the leading causes of
death, worldwide. The future burden of cancer will probably be even larger because people …

Comprehensive review on the Bis–heterocyclic compounds and their anticancer efficacy

MHA Al-Jumaili, AA Hamad, HE Hashem… - Journal of Molecular …, 2023 - Elsevier
Heterocyclic compounds are one of the largest family of organic compounds with broad
range of applications in medicinal chemistry and agrochemicals product. Bis-heterocycle …

[PDF][PDF] Pharmacological significance of synthetic heterocycles scaffold: a review

R Dua, S Shrivastava, SK Sonwane… - Advances in Biological …, 2011 - researchgate.net
Heterocyclic chemistry offers an example for the lack of distinct demarcations; in fact, it
pervades the plurality of the other chemical disciplines. Heterocycles are inextricably woven …

A comprehensive review of N-heterocycles as cytotoxic agents

D Kumar, S Kumar Jain - Current Medicinal Chemistry, 2016 - ingentaconnect.com
Scientific community is striving to understand the role of heterocycles and fused
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …

[图书][B] Heterocyclic chemistry in drug discovery

JJ Li - 2013 - books.google.com
Enables researchers to fully realize the potential to discover new pharmaceuticals among
heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this …

Nitrogen-containing heterocycles as anticancer agents: An overview

DK Lang, R Kaur, R Arora, B Saini… - Anti-Cancer Agents in …, 2020 - ingentaconnect.com
Background: Cancer is spreading all over the world, and it is becoming the leading cause of
major deaths. Today's most difficult task for every researcher is to invent a new drug that can …