Publisher Summary Transcriptional Control of the Human Apolipoprotein B Gene in Cell
Culture and in This chapter discusses the recent progress in three major areas of work, with …

Apolipoprotein B (ApoB) is a major constituent of the plasma lipoproteins. In adult mammals
it is synthesized in two different tissues, liver and intestine. We have examined the promoter …

Extensive manipulation of the apolipoprotein B gene in yeast and bacterial artificial
chromosome clones and subsequent expression of these clones in transgenic mice have …

An 87-kilobase (kb) P1 bacteriophage clone (p649) spanning the mouse apolipoprotein
(apo) B gene was used to generate transgenic mice that express high levels of mouse apoB …

The human apolipoprotein B (apoB) gene codes for two related proteins, apoB-100 and
apoB-48. ApoB-100 is synthesized in the liver, is the major protein constituent of low density …

Apolipoprotein B is a large, amphipathic protein that plays a central role in lipoprotein
metabolism. Because its overproduction and deficiency leads to metabolic and pathologic …

To identify DNA sequence elements from the human apolipoprotein B (apoB) gene required
for high-level, correct tissue-specific expression in transgenic mice, we made several …

Recombinant cDNA clones that code for apolipoprotein B (apoB) were isolated from a rat
liver cDNA library, using synthetic oligonucleotide probe derived from the sequence of …

Apolipoprotein B (apo-B) plays a crucial role in the assembly of lipoproteins in the liver and
the intestine. Here, we review how transgenic mouse expression studies with large genomic …

We recently reported that an 8-kilobase (kb) region, spanning from− 54 to− 62 kb 5′ of the
human apolipoprotein B (apoB) gene, contains intestine-specific regulatory elements that …