Importance Polygenic risk scores (PRS) are predictors of the genetic susceptibilities of
individuals to diseases. All individuals have DNA risk variants for all common diseases, but …

Purpose: Disease-causing mutations and pharmacogenomic variants are of primary interest
for clinical whole-genome sequencing. However, estimating genetic liability for common …

Background Polygenic risk scores (PRS) are valuable to translate the results of genome-
wide association studies (GWAS) into clinical practice. To date, most GWAS have been …

The use of genomic information to better understand and prevent common complex
diseases has been an ongoing goal of genetic research. Over the past few years, research …

Motivation It is hoped that advances in our knowledge in disease genomics will contribute to
personalized medicine such as individualized preventive strategies or early diagnoses of …

Background Polygenic risk scores (PRSs) can stratify populations into cardiovascular
disease (CVD) risk groups. We aimed to quantify the potential advantage of adding …

Background: Understanding the predictive utility of previously derived polygenic risk scores
(PRSs) for long-term risk of coronary heart disease (CHD) and its additive value beyond …

A key public health need is to identify individuals at high risk for a given disease to enable
enhanced screening or preventive therapies. Because most common diseases have a …

Transitions from health to disease are characterized by dysregulation of biological networks
under the influence of genetic and environmental factors, often over the course of years to …

Background: Individual risk prediction based on genome-wide polygenic risk scores (PRSs)
using millions of genetic variants has attracted much attention. It is under debate whether …