After decades of research, the sigma-1 receptor (Sig-1R)'s structure, and molecular functions
are being unveiled. Sig-1R is an integral endoplasmic reticulum (ER) membrane protein …

Sigma-1 receptors (Sig-1Rs) have been implicated in many neurological and psychiatric
conditions. Sig-1Rs are intracellular chaperones that reside specifically at the endoplasmic …

Abstract Sigma-1 receptor (Sig-1R) is a protein present in several organs such as brain,
lung, and heart. In a cell, Sig-1R is mainly located across the membranes of the …

Abstract The sigma-1 receptor (Sig-1R) is a single 25 kD polypeptide and a chaperone
protein immersed in lipid rafts of the endoplasmic reticulum (ER) where it interacts with …

Introduction: Sigma-1 receptors (Sig-1Rs) are molecular chaperones that reside mainly in
the endoplasmic reticulum (ER) but exist also in the proximity of the plasma membrane. Sig …

A large body of evidence indicates that sigma-1 receptors (Sig-1R) are important drug
targets for a number of neuropsychiatric disorders. Sig-1Rs are enriched in central nervous …

Abstract The sigma-1 receptor (Sig-1R) is encoded by the SIGMAR1 gene and is a
nonopioid transmembrane receptor located in the mitochondrial-associated endoplasmic …

The sigma-1 receptor (Sig-1R) is a chaperone receptor that primarily resides at the
mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) and acts as a …

Introduction: Current drugs for the treatment of psychiatric or neurodegenerative disorders
have limitations. Psychotherapeutic drugs such as typical and atypical antipsychotics …

Inter-organelle signaling plays important roles in many physiological functions. Endoplasmic
reticulum (ER)–mitochondrion signaling affects intramitochondrial calcium (Ca 2+) …