There is now much interest in the mechanisms by which altered lipid metabolism might
contribute to insulin resistance as is found in Syndrome X or in Type II diabetes. This review …

This review considers evidence for, and putative mechanisms of, lipid-induced muscle
insulin resistance. Acute free fatty acid elevation causes muscle insulin resistance in a few …

Studies in genetic and dietary obese animal models, genetically modified animals and
humans with obesity or type 2 diabetes suggest plausible mechanisms for effects of fatty …

There is interest in how altered lipid metabolism could contribute to muscle insulin
resistance. Many animal and human states of insulin resistance have increased muscle …

Obesity predisposes individuals to the development of insulin resistance, which is a risk
factor for type 2 diabetes, and muscle plays a central role in this phenomenon. Insulin …

Insulin resistance—an impairment in the ability of insulin to appropriately regulate glucose
and lipid metabolism—is an early and key defect associated with weight gain (obesity), type …

Insulin resistance is a major risk factor for numerous diseases, including type 2 diabetes and
cardiovascular disease. These disorders have dramatically increased in incidence with …

The inability of insulin to stimulate glucose metabolism in skeletal muscle is a classic
characteristic of type 2 diabetes, but this insulin resistance entails altered patterns of lipid …

The inhibiting effect of insulin on the mobilization of free fatty acids (FFA) from adipose tissue
is halted in prevalent conditions with systemic insulin resistance. The nature and cause of …

Skeletal muscle insulin resistance is a co-morbidity of obesity and a risk factor for the
development of type 2 diabetes mellitus. Insulin resistance is associated with the …