Cyclic Analogs of Desferrioxamine E Siderophore for 68Ga Nuclear Imaging: Coordination Chemistry and Biological Activity in Staphylococcus aureus

A Mular, A Shanzer, H Kozłowski, I Hubmann… - Inorganic …, 2021 - ACS Publications
As multidrug-resistant bacteria are an emerging problem and threat to humanity, novel
strategies for treatment and diagnostics are actively sought. We aim to utilize siderophores …

[HTML][HTML] Siderophores for molecular imaging applications

M Petrik, C Zhai, H Haas, C Decristoforo - Clinical and translational …, 2017 - Springer
This review covers publications on siderophores applied for molecular imaging applications,
mainly for radionuclide-based imaging. Siderophores are low molecular weight chelators …

67Ga-labeled deferoxamine derivatives for imaging bacterial infection: Preparation and screening of functionalized siderophore complexes

JA Ioppolo, D Caldwell, O Beiraghi, L Llano… - Nuclear Medicine and …, 2017 - Elsevier
Introduction Deferoxamine (DFO) is a siderophore that bacteria use to scavenge iron and
could serve as a targeting vector to image bacterial infection where current techniques have …

[HTML][HTML] 68Ga-labelled desferrioxamine-B for bacterial infection imaging

M Petrik, E Umlaufova, V Raclavsky, A Palyzova… - European journal of …, 2021 - Springer
Purpose With the increase of especially hospital-acquired infections, timely and accurate
diagnosis of bacterial infections is crucial for effective patient care. Molecular imaging has …

Optimization of Artificial Siderophores as 68Ga-Complexed PET Tracers for In Vivo Imaging of Bacterial Infections

C Peukert, LNB Langer, SM Wegener… - Journal of Medicinal …, 2021 - ACS Publications
The diagnosis of bacterial infections at deep body sites benefits from noninvasive imaging of
molecular probes that can be traced by positron emission tomography (PET). We specifically …

Theranostic gallium siderophore ciprofloxacin conjugate with broad spectrum antibiotic potency

A Pandey, C Savino, SH Ahn, Z Yang… - Journal of medicinal …, 2019 - ACS Publications
Pathogenic bacteria scavenge ferric iron from the host for survival and proliferation using
small-molecular chelators, siderophores. Here, we introduce and assess the gallium (III) …

[HTML][HTML] In vitro and in vivo evaluation of selected 68Ga-siderophores for infection imaging

M Petrik, H Haas, M Schrettl, A Helbok, M Blatzer… - Nuclear medicine and …, 2012 - Elsevier
INTRODUCTION: Siderophores are low-molecular-mass iron chelators serving as iron
transporters for almost all bacteria, fungi and some plants. Iron is an essential element for …

Siderophores for medical applications: imaging, sensors, and therapeutics

D Fan, Q Fang - International Journal of Pharmaceutics, 2021 - Elsevier
Siderophores are low-molecular-weight chelators produced by microorganisms to scavenge
iron from the environment and deliver it to cells via specific receptors. Tremendous …

[HTML][HTML] In Vitro and In Vivo Comparison of Selected Ga-68 and Zr-89 Labelled Siderophores

M Petrik, C Zhai, Z Novy, L Urbanek, H Haas… - Molecular Imaging and …, 2016 - Springer
Abstract Purpose Some [68 Ga] siderophores show promise in specific and sensitive
imaging of infection. Here, we compare the in vitro and in vivo behaviour of selected Ga-68 …

[HTML][HTML] A novel radiolabelled salmochelin derivative for bacteria-specific PET imaging: synthesis, radiolabelling and evaluation

R Margeta, S Schelhaas, S Hermann… - Chemical …, 2024 - pubs.rsc.org
For specific imaging of bacterial infections we aimed at targeting the exclusive bacterial iron
transport system via siderophore-based radiotracers. De novo synthesis and radiolabeling …