A positive feedback loop of IL-17B-IL-17RB activates ERK/β-catenin to promote lung cancer metastasis
Inflammation contributes to the development and progression of cancer. Interleukin-17 (IL-
17) is an inflammatory cytokine that functions in inflammation and cancer, as well as several …
17) is an inflammatory cytokine that functions in inflammation and cancer, as well as several …
Non-tumor tissue derived interleukin-17B activates IL-17RB/AKT/β-catenin pathway to enhance the stemness of gastric cancer
Q Bie, C Sun, A Gong, C Li, Z Su, D Zheng, X Ji, Y Wu… - Scientific reports, 2016 - nature.com
Inflammation is a critical component involved in tumor progression. Interleukin-17 (IL-17)
belongs to a relatively new family of cytokines that has been associated with the progression …
belongs to a relatively new family of cytokines that has been associated with the progression …
IL-17A/IL-17RA promotes invasion and activates MMP-2 and MMP-9 expression via p38 MAPK signaling pathway in non-small cell lung cancer
Z Wu, D He, S Zhao, H Wang - Molecular and cellular biochemistry, 2019 - Springer
The present study is to investigate the effect and mechanism of action of interleukin (IL)-17A
and its receptor IL-17RA on non-small cell lung cancer (NSCLC). A total of 139 NSCLC …
and its receptor IL-17RA on non-small cell lung cancer (NSCLC). A total of 139 NSCLC …
Interleukin-22 promotes lung cancer cell proliferation and migration via the IL-22R1/STAT3 and IL-22R1/AKT signaling pathways
Y Bi, J Cao, S Jin, L Lv, L Qi, F Liu, J Geng… - Molecular and cellular …, 2016 - Springer
Lung cancer continues to be an enormous burden on current health care systems
throughout the world, with more than a million deaths every year. Previous studies have …
throughout the world, with more than a million deaths every year. Previous studies have …
IL-17RB enhances thyroid cancer cell invasion and metastasis via ERK1/2 pathway-mediated MMP-9 expression
L Ren, Y Xu, C Liu, S Wang, G Qin - Molecular Immunology, 2017 - Elsevier
IL-17RB, a member of the IL-17 receptor family that can be activated by IL-17B, has been
proved to be involved in inflammatory diseases and cancers. However, the function of IL …
proved to be involved in inflammatory diseases and cancers. However, the function of IL …
IL-17A promotes tumorigenesis and upregulates PD-L1 expression in non-small cell lung cancer
H Liao, X Chang, L Gao, C Ye, Y Qiao, L Xie… - Journal of translational …, 2023 - Springer
Background The tumor microenvironment plays a key role in non-small cell lung cancer
(NSCLC) development and also influences the effective response to immunotherapy. The …
(NSCLC) development and also influences the effective response to immunotherapy. The …
IL-17A and IL-17F orchestrate macrophages to promote lung cancer
N Ferreira, I Mesquita, F Baltazar, R Silvestre… - Cellular Oncology, 2020 - Springer
Purpose Previously, inflammation has been found to be associated with the development of
lung cancer. Despite their well-characterized pro-inflammatory functions, the putative roles …
lung cancer. Despite their well-characterized pro-inflammatory functions, the putative roles …
[HTML][HTML] Interleukin-22 secreted by cancer-associated fibroblasts regulates the proliferation and metastasis of lung cancer cells via the PI3K-Akt-mTOR signaling …
H Li, Q Zhang, Q Wu, Y Cui, H Zhu, M Fang… - American journal of …, 2019 - ncbi.nlm.nih.gov
Lung cancer is one of the most common human cancers and is the leading cause of cancer-
related mortality. Previous studies have suggested that IL-22 might promote the survival of …
related mortality. Previous studies have suggested that IL-22 might promote the survival of …
[HTML][HTML] IL-13 receptor α2 is a negative prognostic factor in human lung cancer and stimulates lung cancer growth in mice
M Xie, X Wu, J Zhang, C He - Oncotarget, 2015 - ncbi.nlm.nih.gov
Abstract IL-13 receptor subunit alpha-2 (IL13Rα2) is associated with poor prognosis in some
cancers. However, the role of IL13Rα2 in lung cancer remains unknown. We showed that …
cancers. However, the role of IL13Rα2 in lung cancer remains unknown. We showed that …
[HTML][HTML] Interleukin-17-induced EMT promotes lung cancer cell migration and invasion via NF-κB/ZEB1 signal pathway
K Gu, MM Li, J Shen, F Liu, JY Cao… - American journal of …, 2015 - ncbi.nlm.nih.gov
Abstract Inflammatory cytokine interleukin-17 (IL-17) has been associated with the risk of
progressive cancers including lung cancer. However, it remains unclear how IL-17 may …
progressive cancers including lung cancer. However, it remains unclear how IL-17 may …